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Kinetics and Mechanism of Methanol and Formaldehyde Interconversion and Formaldehyde Oxidation Catalyzed by Liver Alcohol Dehydrogenase

  • Y. Pocker
  • Hong Li
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 284)

Abstract

Liver alcohol dehydrogenase (LADH) is a well-characterized protein. Both its primary and tertiary structures are known, as are some of the catalytic mechanisms, isozyme differences, evolutionary divergences and a number of enzymatic properties (Jörnvall, 1970; Brändén, et al., 1975; Klinman, 1981; Eklund and Brändén, 1983; Pettersson, 1987; Pocker, 1989). In contrast, relatively little is known about its interaction with methanol, although there is extensive structural homology between this compound and ethanol.

Keywords

Alcohol Dehydrogenase Formaldehyde Oxidation Methanol Oxidation Primary Alcohol Product Inhibition 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1990

Authors and Affiliations

  • Y. Pocker
    • 1
  • Hong Li
    • 1
  1. 1.Department of ChemistryUniversity of WashingtonSeattleUSA

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