Kinetics and Mechanism of Methanol and Formaldehyde Interconversion and Formaldehyde Oxidation Catalyzed by Liver Alcohol Dehydrogenase

  • Y. Pocker
  • Hong Li
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 284)


Liver alcohol dehydrogenase (LADH) is a well-characterized protein. Both its primary and tertiary structures are known, as are some of the catalytic mechanisms, isozyme differences, evolutionary divergences and a number of enzymatic properties (Jörnvall, 1970; Brändén, et al., 1975; Klinman, 1981; Eklund and Brändén, 1983; Pettersson, 1987; Pocker, 1989). In contrast, relatively little is known about its interaction with methanol, although there is extensive structural homology between this compound and ethanol.


Alcohol Dehydrogenase Formaldehyde Oxidation Methanol Oxidation Primary Alcohol Product Inhibition 
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Copyright information

© Plenum Press, New York 1990

Authors and Affiliations

  • Y. Pocker
    • 1
  • Hong Li
    • 1
  1. 1.Department of ChemistryUniversity of WashingtonSeattleUSA

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