Glutathione-Dependent Formaldehyde Dehydrogenase (EC Evidence for the Identity with Class III Alcohol Dehydrogenase

  • Martti Koivusalo
  • Lasse Uotila
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 284)


The glutathione-dependent formaldehyde dehydrogenase (EC is a ubiquitous cytoplasmic enzyme, which was first described in 1955 Strittmatter and Ball from beef and chicken livers. It was purified to homogeneity and characterized from human liver by Uotila and Koivusalo in 1974 (1974a) and has later also been purified from some other sources (Uotila and Koivusalo 1989, Pourmotabbed et al. 1989). Formaldehyde ehydrogenase catalyzes the following reversible reaction:
$$Formaldehyde + GSH + NA{D^ + } \leftrightarrow S - formylglutathione + NADH + {H^ + }$$


Alcohol Dehydrogenase Chromotropic Acid Formaldehyde Dehydrogenase Horse Liver Alcohol Dehydrogenase Nicotinamide Nucleotide 
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Copyright information

© Plenum Press, New York 1990

Authors and Affiliations

  • Martti Koivusalo
    • 1
  • Lasse Uotila
    • 1
  1. 1.Department of Medical ChemistryUniversity of HelsinkiHelsinkiFinland

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