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Glutathione-Dependent Formaldehyde Dehydrogenase (EC 1.2.1.1): Evidence for the Identity with Class III Alcohol Dehydrogenase

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Enzymology and Molecular Biology of Carbonyl Metabolism 3

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 284))

Abstract

The glutathione-dependent formaldehyde dehydrogenase (EC 1.2.1.1) is a ubiquitous cytoplasmic enzyme, which was first described in 1955 Strittmatter and Ball from beef and chicken livers. It was purified to homogeneity and characterized from human liver by Uotila and Koivusalo in 1974 (1974a) and has later also been purified from some other sources (Uotila and Koivusalo 1989, Pourmotabbed et al. 1989). Formaldehyde ehydrogenase catalyzes the following reversible reaction:

$$Formaldehyde + GSH + NA{D^ + } \leftrightarrow S - formylglutathione + NADH + {H^ + }$$

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Authors and Affiliations

  1. Department of Medical Chemistry, University of Helsinki, SF-00170, Helsinki, Finland

    Martti Koivusalo & Lasse Uotila

Authors
  1. Martti Koivusalo
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  2. Lasse Uotila
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Editor information

Editors and Affiliations

  1. Department of Biochemistry, Purdue University, West Lafayette, Indiana, 47907, USA

    Henry Weiner

  2. Chemisches Zentrallabor, Inselspital, Bern, CH 3010, Switzerland

    Bendicht Wermuth

  3. Indiana University School of Medicine and Veterans Administration Medical Center, Indianapolis, Indiana, 46202, USA

    David W. Crabb

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© 1990 Plenum Press, New York

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Koivusalo, M., Uotila, L. (1990). Glutathione-Dependent Formaldehyde Dehydrogenase (EC 1.2.1.1): Evidence for the Identity with Class III Alcohol Dehydrogenase. In: Weiner, H., Wermuth, B., Crabb, D.W. (eds) Enzymology and Molecular Biology of Carbonyl Metabolism 3. Advances in Experimental Medicine and Biology, vol 284. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5901-2_33

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  • DOI: https://doi.org/10.1007/978-1-4684-5901-2_33

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-5903-6

  • Online ISBN: 978-1-4684-5901-2

  • eBook Packages: Springer Book Archive

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