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Role of Alcohol Dehydrogenase Polymorphism in Ethanol Metabolism and Alcohol-Related Diseases

  • Patrice Couzigou
  • Benoît Fleury
  • Alexis Groppi
  • Albert Iron
  • Christiane Coutelle
  • André Cassaigne
  • Joël Bégueret
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 284)

Abstract

In alcohol toxicity, a lot of data point to genetic factors associated with environmental factors. These genetic factors can intervene at different levels : genetic variability in the distribution of polymorphic alcohol and aldehyde dehydrogenase isozymes (Bosron, et al., 1988) could play a role in determining individual difference in ethanol metabolism and toxicity. In the future, other polymorphisms in alcohol metabolism may be described. Polymorphism is also to be considered in detoxication and/or target organ metabolism (as collagen polymorphism in alcoholic cirrhosis)(Weiner, et al., 1988).

Keywords

Alcohol Dehydrogenase Alcoholic Cirrhosis Moderate Alcohol Consumption Ethanol Metabolism Collagen Polymorphism 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1990

Authors and Affiliations

  • Patrice Couzigou
    • 1
    • 2
  • Benoît Fleury
    • 1
    • 2
  • Alexis Groppi
    • 1
    • 2
  • Albert Iron
    • 1
    • 2
  • Christiane Coutelle
    • 1
    • 2
  • André Cassaigne
    • 1
    • 2
  • Joël Bégueret
    • 1
    • 2
  1. 1.Departement of HepatogastroenterologyHopital Haut-LévêquePessacFrance
  2. 2.Department of Genetics and BiochemistryUniversity Bordeaux IIBordeauxFrance

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