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Study on Dihydrodiol Dehydrogenase (II) Modulation of Dihydrodiol Dehydrogenase Activity by Biological Disulfides

  • Tomoyuki Terada
  • Kazuhiko Shinagawa
  • Toshifumi Umemura
  • Tohru Nishinaka
  • Hirofumi Nanjo
  • Saburo Hosomi
  • Tadashi Mizoguchi
  • Tsutomu Nishihara
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 284)

Abstract

Rat liver cytosolic 3α-hydroxysteroid dehydrogenase (EC 1.1.1.50) (dihydrodiol dehydrogenase) which can catalyze the conversion between androsterone and androstanedione in the presence of NADP(H) has also been shown to catalyze the oxidation of benzenedihydrodiol to catechol (Penning et al, 1984, 1985; Hara et al., 1988). From the facts that can oxidize the trans-dihydrodiol of polycyclic aromatic hydrocarbons such as benzo(a)pyrene and benzo(a)anthracene, it has been suggested that dihydrodiol dehydrogenase plays an important role in the detoxification of the polycyclic aromatic hydrocarbon through the effective suppression in the formation of the ultimate carcinogenic anti-diol epoxides (Penning et al., 1984, 1985).

Keywords

Polycyclic Aromatic Hydrocarbon Carbonyl Compound Liver Cytosol Aldehyde Reductase Remaining Activity 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1990

Authors and Affiliations

  • Tomoyuki Terada
    • 1
  • Kazuhiko Shinagawa
    • 1
  • Toshifumi Umemura
    • 1
  • Tohru Nishinaka
    • 1
  • Hirofumi Nanjo
    • 1
  • Saburo Hosomi
    • 1
  • Tadashi Mizoguchi
    • 1
  • Tsutomu Nishihara
    • 1
  1. 1.Laboratory of Biochemistry, Faculty of Pharmaceutical SciencesOsaka UniversitySuita, Osaka 565Japan

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