Purification of Aldose and Aldehyde Reductases from Dog Kidney
A broad family of NADPH-dependent oxidoreductases catalyze the reduction of various aldehydes and ketones to their corresponding alcohols. Members include the enzymes aldose reductase (EC 126.96.36.199), aldehyde reductase (EC 188.8.131.52) and carbonyl reductase (EC 184.108.40.206). Aldose reductase and aldehyde reductase, discovered by Hers (1960) in the late 1950’s, were named for their ability to reduce aldonic sugars versus aliphatic and aromatic aldehydes (Felsted and Bachur, 1980; Turner and Flynn, 1982). Aldehyde reductase, however, is also known as L-hexonate dehydrogenase (EC 220.127.116.11) because of its ability to utilize NADP+ to oxidize aldonic acids such as L-gulonate to D-glucuronate (Mano et al., 1961). Carbonyl reductase was first described in the 1970’s as “aromatic aldehyde and ketone reductase” by Culp and McMahon (1968). More recently, it has been referred to as carbonyl reductase (Wermuth, 1981) .
KeywordsAromatic Aldehyde Aldose Reductase Aldose Reductase Inhibitor Carbonyl Reductase Aldehyde Reductase
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- Kador, P.F., Goosey, J.D., Sharpless, N.E., Kolish, J. and Miller, D.D., 1981, Stereospecific inhibition of aldose reductase, Eur. J. Med. Chem. ,16:293.Google Scholar
- Sato, S., 1990, Polyol formation in rat kidney, in:“U.S.-Japan Aldose Reductase Workshop,” N. Hotta, ed., in pressGoogle Scholar
- Sato, S. and Kador, P.F., 1990, Inhibition of aldehyde reductase by aldose reductase inhibitors, Biochem. Pharmacol,in press.Google Scholar
- Sato, S., Kador, P.F. and Kinoshita, J.H., 1988, Rat kidney aldehyde reductase: Purification and comparison with rat lens aldose reductase, in: “Polyol Pathway and its Role in Diabetic Complications,” N. Sakamoto, J.H. Kinoshita, P.F. Kador, and N. Hotta, eds, Excepta Medica, Elsevier Science Publishers B.V., Amsterdam.Google Scholar
- Terubayashi, H., Sato, S., Kador, P.F. and Kinoshita, J.H., 1988, Aldose and aldehyde reductase in the kidney, in:“Polyol Pathway and its Role in Diabetic Complications,” N. Sakamoto, J.H. Kinoshita, P.F. Kador, and N. Hotta, eds, Excepta Medica, Elsevier Science Publishers B.V., Amsterdam.Google Scholar