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In Vitro Expression of Human Placental Aldose Reductase in Escherichia Coli

  • Deborah Carper
  • Sanai Sato
  • Susan Old
  • Stephen Chung
  • Peter F. Kador
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 284)

Abstract

Aldose reductase (alditol: NADP+ oxidoreductase, EC 1.1.1.21, AR) reduces glucose to sorbitol. The accumulation of sorbitol has been implicated in the secondary complication of diabetes, including retinopathy, cataracts, neuropathy and nephropathy (Kinoshita, et al., 1990; Kador, 1988; Dvornik, 1987; Kinoshita, 1974). Blocking the accumulation of sorbitol with a number of aldose reductase inhibitors has proven to be effective in preventing or retarding several clinical complications associated with diabetes in galactosemic and diabetic animal models (Kinoshita, et al., 1990; Robison, et al., 1989; Kador, et al., 1988; Fukushi, Merola and Kinoshita, 1983; Yue, et al., 1982). Aldose reductase inhibitors have also shown promise in clinical studies (Sakamoto, et al., 1986; Judzewitsch, et al., 1983).

Keywords

Aldose Reductase Aldose Reductase Inhibitor Aldehyde Reductase Aldose Reductase Activity Human Placental Tissue 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Chung, S. and La Mendola, J., 1989, Cloning and sequencing determination of human placental aldose reductase gene, J. Biol. Chem., 264:14775.PubMedGoogle Scholar
  2. Dvornik, D., 1987, Complications of chronic diabetes in man and their relation to hyperglycemia, in: An Approach to the Prevention of Diabetic Complications, D. Porte, ed., McGraw-Hill, New York.Google Scholar
  3. Fukushi, S., Merola, L.O. and Kinoshita, J.H., 1980, Altering the course of cataracts in diabetic rats, Invest. Ophthalmol. Vis. Sci. 19:313.PubMedGoogle Scholar
  4. Grundmann, U., Bohn, H., Obermeier, R. and Amann, E., 1990, Cloning and prokaryotic expression of a biologically active human placental aldose reductase, DNA and Cell Biology ,9:149.PubMedCrossRefGoogle Scholar
  5. Hermann, R.K., Kador, P.F. and Kinoshita, J.H., 1983, Rat lens aldose reductase: rapid purification and comparison with human placental aldose reductase, Invest. Ophthalmol. Vis. Sci. ,37:467.Google Scholar
  6. Judzewitsch, R.G., Jaspan, J.B., Polonsky, K.S., Weinberg, C.R., Halter, J.B., Halar, E., Pfeifer, M.A., Vukadinovac, C., Bernstein, L., Schneider, M., Liang, K-Y, Gabbay, K.., Rubenstein, A.H. and Porte, D., Jr, 1983, Aldose reductase inhibition improves nerve conduction velocity in diabetic patients, N. Eng. J. Med. ,308:119.CrossRefGoogle Scholar
  7. Kador, P.F., 1988, The role of aldose reductase in the development of diabetic complications, Medicinal Research Reviews ,8:325.PubMedCrossRefGoogle Scholar
  8. Kador, P.F., Akagi, Y., Terubayashi, H., Wyman, M. and Kinoshita, J.H., 1988, Prevention of pericyte ghost formation in retinal capillaries of galactose-fed dogs by aldose reductase inhibitors, Arch. Ophthalmol. ,106:1099.PubMedCrossRefGoogle Scholar
  9. Kador, P.F., Carper, D. and Kinoshita, J.H., 1981, Rapid purification of human placental aldose reductase, Anal. Biochem. ,114:53.PubMedCrossRefGoogle Scholar
  10. Kinoshita, J.H., Datiles, M.B., Kador, P.F. and Robison, W.G., 1990, Aldose reductase and diabetic eye complications, in: Diabetes Mellitus:Theory and Practice, H. Rifkin and D. Porte, Jr., eds., Elsevier, New York.Google Scholar
  11. Kinoshita, J.H., 1974, Mechanisms initiating cataract formation, Invest. Ophthalmol. Vis. Sci. ,13:713.Google Scholar
  12. Nishimura, C., Matsuura, Y., Kokai, Y., Akera, T., Carper, D., Morjana, N., Lyons, C., and Flynn, T.G., 1990, Cloning and expression human aldose reductase, J. Biol. Chem. ,265:9788.PubMedGoogle Scholar
  13. Robison, G.W.,Jr., Nagata, M., Laver, N., Hohman, T and Kinoshita, J.H., 1989, Diabetic-like retinopathy in rats prevented with an aldose reductase inhibitor, Invest. Ophthalmol. Vis. Sci. ,30:2285.PubMedGoogle Scholar
  14. Sakamoto, N., Kinoshita, J.H., Kador, P.F. and Hotta, N., eds., Polyol Pathway and Its Role in Diabetic Complications: Proceedings of the International Symposium on Polyol Pathway and Its Role in Diabetic Complications, Kashikojima, Japan, 28–30 October, 1986, pp. 1–584, Excerpta Medica, Amsterdam.Google Scholar
  15. Sato, S. and Kador, P.F., 1990, NADPH-dependent reductases of the dog lens, Exp. Eye Res. ,50:629.PubMedCrossRefGoogle Scholar
  16. Sawada, H., Hamatake, M., Hara, A., Nakagawa, M. and Nakayama, T., 1989, Inhibition of human placenta aldose reductase by tannic acid, Chem. Pharm. Bull. ,37:1662.PubMedCrossRefGoogle Scholar
  17. Shiono, T., Sato, S., Reddy, V.N., Kador, P.F. and Kinoshita, J.H., 1987, Purification and properties of rat lens aldose reductase, Prog. Clin. Biol. Res. ,232:317.PubMedGoogle Scholar
  18. Old, S.E., Sato, S., Kador, P.F. and Carper, D.A., 1990, In vitro expression of rat lens aldose reductase in Escherichia coli ,Proc. Natl. Acad. Sci. ,USA. ,in press.Google Scholar
  19. Vander Jagt, D.L., Stangebye, L.A., Hunsaker, L.A., Eaton, R.P. andSibbitt, W.L., 1988, Purification of aldose reductase from human placenta and stabilization of the inhibitor binding site, Biochem. Pharm. ,37:1051.CrossRefGoogle Scholar
  20. Yue, D.K., Hanwell, M.A., Satchell, P.M. and Turtle, J.R., 1982, The effect of aldose reductase inhibition on motor nerve conduction velocity in diabetic rats, Diabetes 31:789.PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1990

Authors and Affiliations

  • Deborah Carper
    • 1
  • Sanai Sato
    • 1
  • Susan Old
    • 1
  • Stephen Chung
    • 2
  • Peter F. Kador
    • 1
  1. 1.National Eye InstituteNIHBethesdaUSA
  2. 2.Eugene Tech InternationalAllendaleUSA

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