cDNA Cloning and Expression of Human Aldose Reductase

  • Chihiro Nishimura
  • Yoshiharu Matsuura
  • Tsuyoshi Tanimoto
  • Takashi Yamaoka
  • Tai Akera
  • T. Geoffrey Flynn
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 284)


Aldose reductase (ALR2; EC, a member of the monomeric NADPH-dependent aldoketoreductase family, has been strongly suggested to play a key role in the development of various diabetic complications (Gabbay et al., 1966; Engerman and Kern, 1984; Nishimura et al., 1987; Kinoshita and Nishimura, 1988).


Duchenne Muscular Dystrophy Aldose Reductase Duchenne Muscular Dystrophy Partial Amino Acid Sequence Beta Strand 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Plenum Press, New York 1990

Authors and Affiliations

  • Chihiro Nishimura
    • 1
  • Yoshiharu Matsuura
    • 2
  • Tsuyoshi Tanimoto
    • 3
  • Takashi Yamaoka
    • 1
  • Tai Akera
    • 1
  • T. Geoffrey Flynn
    • 4
  1. 1.Dept. of Pediatric Pharmacol.Natl. Children’s Med. Res. Ctr.TokyoJapan
  2. 2.Dept. of Vet. Sci.Natl. Institute of HealthTokyoJapan
  3. 3.Div. of Biol. Chem.Natl. Institute of Hygienic Sci.TokyoJapan
  4. 4.Dept. of Biochem.Queen’s University KingstonCanada

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