Structural Studies of Pig Lens Aldose Reductase: Reversible Dimerization of the Enzyme
Drugs inhibiting Aldose Reductase (AR) may have a profound therapeutic impact for patients suffering for diabetes Mellitus. However, a prerequisite for such a long term treatment is the absence of side effects. For the drug design, the knowledge of the structure of AR will be a most useful contribution and will answer a number of puzzling facts such as the surprisingly large number of aldehydes which are substrates for AR. In this account, we present preliminary results of a structural study of pig lens Aldose Reductase.
KeywordsAldose Reductase Sedimentation Coefficient Tetragonal Crystal Triclinic Crystal High Performance Size Exclusion Chromatography
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