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Structural Studies of Pig Lens Aldose Reductase: Reversible Dimerization of the Enzyme

  • Jean-Michel Rondeau
  • Dino Moras
  • Frédérique Tête
  • Alberto Podjarny
  • Alain Van Dorsselaer
  • Jean-Marc Reymann
  • Patrick Barth
  • Jean-François Biellmann
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 284)

Abstract

Drugs inhibiting Aldose Reductase (AR) may have a profound therapeutic impact for patients suffering for diabetes Mellitus. However, a prerequisite for such a long term treatment is the absence of side effects. For the drug design, the knowledge of the structure of AR will be a most useful contribution and will answer a number of puzzling facts such as the surprisingly large number of aldehydes which are substrates for AR. In this account, we present preliminary results of a structural study of pig lens Aldose Reductase.

Keywords

Aldose Reductase Sedimentation Coefficient Tetragonal Crystal Triclinic Crystal High Performance Size Exclusion Chromatography 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Fenn, J.B., Mann, M., Meng, CK., Wong, S.F., and Whitehouse,C.M., Electrospray Ionization for Mass Spectrometry of Large Biomolecules, Science, 246: 64, (1989).PubMedCrossRefGoogle Scholar
  2. 2.
    Gilbert, L.M., and Gilbert, G.A., Sedimentation Velocity Measurement of Protein Association, Meth. Enzymol.,27: 273, (1973) .PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1990

Authors and Affiliations

  • Jean-Michel Rondeau
    • 1
  • Dino Moras
    • 2
  • Frédérique Tête
    • 2
  • Alberto Podjarny
    • 2
  • Alain Van Dorsselaer
    • 3
  • Jean-Marc Reymann
    • 4
  • Patrick Barth
    • 4
  • Jean-François Biellmann
    • 4
  1. 1.BiostructureStrasbourgFrance
  2. 2.Laboratoire de Cristallographie Biologique, I.B.M.C.C.N.R.S.StrasbourgFrance
  3. 3.Laboratoire de Chimie Organique des Substances Naturelles, URA 31, Département de ChimieUniversité Louis PasteurStrasbourgFrance
  4. 4.Laboratoire de Chimie Organique Biologique, URA 31, Département de ChimieUniversité Louis PasteurStrasbourgFrance

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