Human and Mouse Hepatic Aldehyde Dehydrogenases Important in the Biotransformation of Cyclophosphamide and the Retinoids
The rate at which aldehyde dehydrogenase-catalyzed biotransformation occurs in various tissues can be of major importance with regard to the ultimate therapeutic efficacy of drugs and other xenobiotics that are aldehydes or that give rise to aldehydes (Sladek, et al., 1989). Examples of such agents are cyclophosphamide and the retinoids, retinol and beta-carotene.
KeywordsRetinoic Acid Aldehyde Dehydrogenase Betaine Aldehyde Succinic Semialdehyde Betaine Aldehyde Dehydrogenase
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- Amatruda, T. T. III and Koeffler, H. P., 1986, Retinoids and cells of the hematopoietic system, in: “Retinoids and Cell Differentiation,”.Sherman, M. I., ed., CRC Press, Boca Raton, pp. 79–104.Google Scholar
- Lee, M.-O. and Sladek, N. E., 1990, Identification of mouse liver aldehyde dehydrogenases that catalyze the oxidation of retinaldehyde to retinoic acid, Fed. Proc.,4:A659.Google Scholar
- Manthey, C. L., 1988, Resolution and characterization of the aldehyde dehydrogenases important in cyclophosphamide metabolism, Ph.D. , .Google Scholar
- Olson, J. A., 1967, The metabolism of vitamin A, Pharmacol. Rev.. ,19:559–596.Google Scholar