Human and Mouse Hepatic Aldehyde Dehydrogenases Important in the Biotransformation of Cyclophosphamide and the Retinoids

  • N. E. Sladek
  • P. A. Dockham
  • M. O. Lee
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 284)


The rate at which aldehyde dehydrogenase-catalyzed biotransformation occurs in various tissues can be of major importance with regard to the ultimate therapeutic efficacy of drugs and other xenobiotics that are aldehydes or that give rise to aldehydes (Sladek, et al., 1989). Examples of such agents are cyclophosphamide and the retinoids, retinol and beta-carotene.


Retinoic Acid Aldehyde Dehydrogenase Betaine Aldehyde Succinic Semialdehyde Betaine Aldehyde Dehydrogenase 
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Copyright information

© Plenum Press, New York 1990

Authors and Affiliations

  • N. E. Sladek
    • 1
  • P. A. Dockham
    • 1
  • M. O. Lee
    • 1
  1. 1.Department of PharmacologyUniversity of MinnesotaMinneapolisUSA

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