Role of Aldehyde Dehydrogenase (ALDH) in the Detoxication of Cyclophosphamide (CP) in Rat Embryos

  • Philip E. Mirkes
  • Aaron Ellison
  • Sally A. Little
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 284)


The carbonyl compound 4-hydroxynonenal is one of the major and most toxic products of the oxidative lipid breakdown of biological membranes. Its formation has been quantified in rat liver homogenates, microsomes and whole parenchymal cells under various conditions of enhanced lipid peroxidation (Benedetti, et al., 1980; Esterbauer, et al., 1982; Poli, et al., 1985,1986).


L1210 Cell Aldehyde Dehydrogenase Heart Cell ALDH Activity Mandibular Arch 
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Copyright information

© Plenum Press, New York 1990

Authors and Affiliations

  • Philip E. Mirkes
    • 2
  • Aaron Ellison
    • 1
  • Sally A. Little
    • 1
  1. 1.Division of Embryology, Teratology and Congenital Defects, Department of PediatricsUniversity of WashingtonSeattleUSA
  2. 2.Child Development and Mental Retardation CenterUniversity of WashingtonUSA

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