Metabolism of 4-Hydroxynonenal in Hepatoma Cell Lines
Peroxidation of membrane lipids is thought be a dynamic process which is ongoing in virtually all cells. Under normal conditions, cellular lipid peroxidation is well regulated and, as noted in a recent review (Esterbauer. et al. , 1990), is always associated with the formation of numerous and chemically diverse aldehydic products. Malondialdehyde (MDA) and trans-4-hydroxy-2-nonenal (HNE) are classified as major products of lipid peroxidation since they are present in the greatest quantities during peroxidation of cellular membrane lipids while trans-2-hexenal, acrolein and crotonaldehdye are representative of minor products of lipid peroxidation thought to be formed in significantly smaller quantities.
KeywordsHepatoma Cell Alcohol Dehydrogenase Cytosolic Fraction Aldehyde Dehydrogenase Glutathione Transferase
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