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Polymer Gels pp 299-308 | Cite as

Thermo-Responsive Polymeric Hydrogels and Their Application to Pulsatile Drug Release

  • Teruo Okano
  • Ryo Yoshida
  • Kiyotaka Sakai
  • Yasuhisa Sakurai

Abstract

Poly(N-isopropyl acrylamide)(IPAAm) has characteristics to exhibit a remarkable swelling change in aqueous system in response to step-wise temperature change. Random copolymers of IPAAm with alkyl methacrylate (RMA) having different length of alkyl side chain were synthesized to achieve complete on-off drug permeation and release in response to step-wise temperature. On-off release and permeation of indomethacin were found to be due to surface shrinking layer with increasing temperature. The formation process of these surface shrinking layers were confirmed to be controlled by alkyl side chain length of RMA. From these results, the effects of chemical structure (length of alkyl side chain) on temperature modulated drug permeation and palsatile drug release pattern have been discussed.

Keywords

Drug Release Alkyl Side Chain Drug Permeation Butyl Methacrylate Alkyl Methacrylate 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1991

Authors and Affiliations

  • Teruo Okano
    • 1
  • Ryo Yoshida
    • 2
  • Kiyotaka Sakai
    • 2
  • Yasuhisa Sakurai
    • 1
  1. 1.Institute of Biomedical EngineeringTokyo Women’s Medical CollegeShinjuku-ku, TokyoJapan
  2. 2.Department of Chemical EngineeringWaseda UniversityShinjuku-ku, TokyoJapan

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