Electric Modulation of Polymer Gel Contraction and Animal cell Proliferation
Modulation of gel morphology of synthetic polymer and biopolymer upon low potential application was investigated. Morphology of polymethacrylic acid (PMAA)-Ca2+ chelate microgels has been electrically modulated on a conducting polymer film-coated electrode. The electrode induced a drastic change of ion flux in the vicinity of the conducting polymer film without any water electrolysis, which caused the PMAA-Ca2+ microgels to change rapidly their shape. Electric effects on animal cells cultured on an electrode were also investigated in this line of study. Morphology and proliferation of HeLa cell was dependent on electrode potential during culture. The modulation mechanism is interpreted in relation to the structural change in cytoskeletal gel composed of F-actin.
KeywordsHeLa Cell Potential Step Water Electrolysis Electric Modulation Polypyrrole Film
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