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Pathogenesis and Immunology of Herpesvirus Infections of the Nervous System

  • Anthony A. Nash
  • J. Matthias Löhr
Part of the Infectious Agents and Pathogenesis book series (IAPA)

Abstract

The herpesviruses are ubiquitous in nature, infecting fish, amphibians, reptiles, birds, and mammals. They are highly successful parasites, requiring only a small host range in which to maintain an infection: typically 102–103 individuals are sufficient to maintain a varicella-zoster virus (VZV) infection in the population, compared with >105 individuals for measles virus.1 The great success of the herpesviruses is attributed to a remarkable strategy for persisting within their host, termed latency. This strategy involves the virus persisting as genetic material, but without expressing any detectable viral proteins and thereby evading host immune defenses. Although the ability to establish a latent infection is a characteristic of all herpesviruses, we consider classical latency to be a property of those viruses involved with infections of the nervous system, notably herpes simplex virus (HSV) types 1 and 2 and VZV.

Keywords

Herpes Simplex Virus Herpes Simplex Virus Type Chronic Fatigue Syndrome Herpes Zoster Herpes Simplex Virus Infection 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1992

Authors and Affiliations

  • Anthony A. Nash
    • 1
  • J. Matthias Löhr
    • 2
  1. 1.Department of PathologyUniversity of CambridgeCambridgeEngland
  2. 2.Department of Internal MedicineUniversity of ErlangenErlangenGermany

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