Neurotropic Retroviruses of Mice, Cats, Macaques, and Humans

  • Murray Gardner
  • Andrew Lackner
  • Linda Lowenstine
Part of the Infectious Agents and Pathogenesis book series (IAPA)


The prominent neurological manifestations associated with infection by the human immunodeficiency virus (HIV) and the human T-lymphotropic retrovirus (HTLV) have focused attention on the neurotropic properties of the family Retroviridae. This family is divided into three subfamilies, the oncoviruses, the lentiviruses, and the spumaviruses, each of which is known to infect the central nervous system (CNS) of their natural animal hosts.1 The only known naturally occurring neurological disease caused by an oncovirus in animals is the spongiform polioencephalomyelopathy caused by murine leukemia virus (MuLV) discovered in the early 1970s in a population of wild mice in southern California (for review, see Gardner2). Since then, several strains of laboratory-derived, temperature-sensitive, and mutant MuLV have produced a similar disease experimentally in mice and rats.3,4


Human Immunodeficiency Virus Simian Immunodeficiency Virus Murine Leukemia Virus Feline Immunodeficiency Virus Wild Mouse 


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Copyright information

© Plenum Press, New York 1992

Authors and Affiliations

  • Murray Gardner
    • 1
  • Andrew Lackner
    • 2
  • Linda Lowenstine
    • 2
  1. 1.Department of Pathology, School of MedicineUniversity of CaliforniaDavisUSA
  2. 2.California Primate Research CenterUniversity of CaliforniaDavisUSA

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