Visna, a Lentiviral Disease of Sheep

  • Gudmundur Pétursson
  • Ólafur S. Andrésson
  • Gudmundur Georgsson
Part of the Infectious Agents and Pathogenesis book series (IAPA)

Abstract

Visna (meaning wasting), an encephalomyelitis, and maedi (meaning dyspnea), an interstitial pneumonia of sheep, were brought to Iceland with imported Karakul sheep in 1933.1 Almost three decades elapsed until the causative agent of visna, a virus, was isolated from the central nervous system (CNS) of visnaaffected sheep.2 A few years later a virus was isolated from the lungs of a sheep with maedi.3 The viruses were shown to be serologically related, and early transmission experiments indicated that visna and maedi were but different organ manifestations of infection with the same virus,4 which is thus frequently referred to as maedi-visna virus (MVV).

Keywords

Arthritis Pneumonia Dementia Retina Interferon 

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References

  1. 1.
    Pâlsson, P. A., 1976, Maedi and visna in sheep, in: Slow Virus Diseases of Animals and Man (R. H. Kimberlin, ed.), North Holland, Amsterdam, pp. 17–43.Google Scholar
  2. 2.
    Sigurdsson, B., Thormar, H., and Pâlsson, P. A., 1960, Cultivation of visna virus in tissue culture, Arch. Ges. Virusforsch. 10: 368–381.CrossRefGoogle Scholar
  3. 3.
    Sigurdardottir, B., and Thormar, H., 1964, Isolation of a viral agent from the lungs of sheep affected with maedi, J. Infect. Dis. 114: 55–60.PubMedCrossRefGoogle Scholar
  4. 4.
    Gudnadóttir, M., and Pâlsson, P. A., 1965, Successful transmission of visna by intrapulmonary inoculation, J. Infect. Dis. 115: 217–225.PubMedCrossRefGoogle Scholar
  5. 5.
    Lin, E. H., and Thormar, H., 1970, Ribonucleic acid-dependent deoxyribonucleic acid polymerase in visna virus, J Virol. 6: 702–704.PubMedGoogle Scholar
  6. 6.
    Stephens, R. M., Casey, J. W, and Rice, N. R., 1986, Equine infectious anemia virus gag and pol genes: Relatedness to visna and AIDS virus, Science 231: 589–594.Google Scholar
  7. 7.
    Sigurdsson, B., 1954, Observations on three slow infections of sheep, Br. Veg. 110: 255–270.Google Scholar
  8. 8.
    Pétursson, G., Pâlsson, P. A., and Georgsson, G., 1989, Maedi—visna in sheep: Host—virus interactions and utilization as a model, Intervirology 30: 36–44.PubMedGoogle Scholar
  9. 9.
    Price, R. W, Brew, B., Sidtis, J., Rosenblum, M., Scheck, A. C., and Cleary, P., 1988, Central nervous system HIV-1 infection and AIDS dementia complex, Science 239: 586–592.PubMedCrossRefGoogle Scholar
  10. 10.
    Pétursson, G., Nathanson, N., Georgsson, G., Panitch, H., and Pâlsson, P. A., 1976, Pathogenesis of visna. I. Sequential virologic, serologic and pathologic studies, Lab. Invest. 35: 402–412.PubMedGoogle Scholar
  11. 11.
    Narayan, O., Strandberg, J. D., Griffin, D. E., Clements, J. E., and Adams, R. J., 1983, Aspects of the pathogenesis of visna in sheep, in: Viruses and Demyelinating Diseases ( C. A. Mims, M. L. Cuzner, and R. E. Kelly, eds.), Academic Press, London, pp. 125–140.Google Scholar
  12. 12.
    Saag, M. S., Hahn, B. H., Gibbons, J., Li, Y., Parks, E. S., Parks, WP., and Shaw, G. M., 1988, Extensive variation of human immunodeficiency virus type-1 in vivo, Nature 334: 440–444.PubMedCrossRefGoogle Scholar
  13. 13.
    Haase, A. T., Garapin, A. C., Faras, A. J., Varmus, H. E., and Bishop, J. M., 1974, Characterization of the nucleic acid product of the visna virus RNA dependent DNA polymerase, Virology 57: 251–258.PubMedCrossRefGoogle Scholar
  14. 14.
    Sonigo, P., Alizon, M., Staskus, K., Klatzmann, D., Cole, S., Danos, O., Retzel, E., Tiollais, P., Haase, A., and Wain-Hobson, S., 1985, Nucleotide sequence of the visna lentivirus: Relationship to the AIDS virus, Cell 42: 369–382.PubMedCrossRefGoogle Scholar
  15. 15.
    Haase, A. T., Stowring, L., Harris, J. D., Traynor, B., Ventura, P., Peluso, R., and Brahic, M., 1982, Visna DNA synthesis and the tempo of infection in vitro, Virology 119: 399–410.PubMedCrossRefGoogle Scholar
  16. 16.
    Vigne, R., Barban, V., Quérat, G., Mazarin, V., Gourdou, I., and Sauze, N., 1987, Transcription of visna virus during its lytic cycle: Evidence for a sequential early and late gene expression, Virology 161: 218–227.PubMedCrossRefGoogle Scholar
  17. 17.
    Davis, J. L., and Clements, J. E., 1988, Complex gene expression of lentiviruses, Microb. Pathogen. 4: 239–245.CrossRefGoogle Scholar
  18. 18.
    Davis, J. L., and Clements, J. E., 1989, Characterization of a cDNA clone encoding the visna virus transactivating protein, Proc. Natl. Acad. Sci. USA 86: 414–418.PubMedCrossRefGoogle Scholar
  19. 19.
    Mazarin, V., Gourdou, I., Quérat, G., Sauze, N., and Vigne, R., 1988, Genetic structure and function of an early transcript of visna virus, J. Virol. 62: 4813–4818.PubMedGoogle Scholar
  20. 20.
    Braun, M. J., Clements, J. E., and Gonda, M. A., 1987, The visna virus genome: Evidence for a hypervariable site in the env gene and sequence homology among lentivirus envelope proteins, J. Virol. 61: 4046–4054.PubMedGoogle Scholar
  21. 21.
    Haase, A. T., and Baringer, J. R., 1974, The structural polypeptides of RNA slow viruses, Virology 57: 238–250.PubMedCrossRefGoogle Scholar
  22. 22.
    Vigne, R., Filippi, P., Quérat, G., Sauze, N., Vitu, C., Russo, P., and Delori, P., 1982, Precursor polypeptides to structural proteins of visna virus, J. Virol. 42: 1046–1056.PubMedGoogle Scholar
  23. 23.
    Pétursson, G., Martin, J. R., Georgsson, G., Nathanson, N., and Pâlsson, P. A., 1979, Visna, the biology of the agent and the disease, in: New Perspectives in Clinical Microbiology, Aspects of Slow and Persistent Virus Infections ( D. A. J. Tyrrell, ed.), Martinus Nijhoff, The Hague, pp. 198–220.Google Scholar
  24. 24.
    Narayan, O., Wolinsky, J. S., Clements, J. E., Strandberg, J. D., Griffin, D. E., and Cork, L. C., 1982, Slow virus replication: The role of macrophages in the persistence and expression of visna viruses of sheep and goats, J. Gen. Virol. 59: 345–356.PubMedCrossRefGoogle Scholar
  25. 25.
    Gendelman, H. E., Narayan, O., Molineux, S., Clements, J. E., and Ghotbi, Z., 1985, Slow persistent replication of lentiviruses: Role of tissue macrophages and macrophage precursors in bone marrow, Proc. Natl. Acad. Sci. U.S.A. 82: 7086–7090.PubMedCrossRefGoogle Scholar
  26. 26.
    Gendelman, H. E., Narayan, O., Kennedy-Stoskopf, S., Kennedy, P. G. E., Ghotbi, Z., Clements, J. E., Stanley, J., and Pezeshkpour, G., 1986, Tropism of sheep lentiviruses for monocytes: Susceptibility to infection and virus gene expression increase during maturation of monocytes to macrophages, J. Virol 58: 67–74.PubMedGoogle Scholar
  27. 27.
    Orenstein, J. M., Meltzer, M. S., Phipps, T., and Gendelman, H. E., 1988, Cytoplasmic assembly and accumulation of human immunodeficiency virus types 1 and 2 in recombinant human colony-stimulating factor-l-treated human monocytes: An ultrastructural study, J. Virol. 62: 2578–2586.PubMedGoogle Scholar
  28. 28.
    Thormar, H., 1976, Visna—maedi infection in cell cultures and in laboratory animals, in: Slow Virus Diseases of Animals and Man ( R. H. Kimberlin, ed.), North-Holland, Amsterdam, pp. 97–114.Google Scholar
  29. 29.
    Macintyre, E. H., Wintersgill, C. J., and Vatter, A. E., 1974, A modification in the response of human astrocytes to visna virus, Am. j Vet. Res. 35: 1161–1163.PubMedGoogle Scholar
  30. 30.
    Georgsson, G., Pâlsson, P. A., and Pétursson, G., 1987, Pathogenesis of visna, in: A Multidisciplinary Approach to Myelin Diseases ( G. Serlupi Crescenzi, ed.), Plenum Press, New York, pp. 303–318.Google Scholar
  31. 31.
    de Boer, G. F., 1970, Zwoegerziekte, a Persistent Infection in Sheep, Thesis, Utrecht.Google Scholar
  32. 32.
    de Boer, G. E, Terpstra, C., and Houwers, D. J., 1979, Studies in epidemiology of maedi/visna in sheep, Res. Vet. Sci. 26: 202–208.PubMedGoogle Scholar
  33. 33.
    Sigurdsson, B., Pâlsson, P. A., and Grímsson, H., 1957, Visna, a demyelinating transmissible disease of sheep, J. Neuropathol. Exp. Neurol. 16: 389–403.PubMedCrossRefGoogle Scholar
  34. 34.
    Sigurdsson, B., Pâlsson, P. A., and van Bogaert, L., 1962, Pathology of visna. Transmissible demyelinating disease in sheep in Iceland, Acta Neuropathol. (Berl.) 1: 343–362.CrossRefGoogle Scholar
  35. 35.
    Narayan, O., Silverstein, A. M., Price, D., and Johnson, R. T., 1974, Visna virus infection of American lambs, Science 183: 1202–1203.PubMedCrossRefGoogle Scholar
  36. 36.
    de Boer, G. E, 1975, Zwoergerziekte virus, the causative agent for progressive interstitial pneumonia (maedi) and meningo-leucoencephalitis (visna) in sheep, Res. Vet. Sci. 18: 15–25.PubMedGoogle Scholar
  37. 37.
    Griffin, D. E., Narayan, O., and Adams, R. J., 1978, Early immune responses in visna, a slow viral disease of sheep, J. Infect. Dis. 138: 340–350.PubMedCrossRefGoogle Scholar
  38. 38.
    Georgsson, G., Nathanson, N., Pâlsson, P. A., and Pétursson, G., 1976, The pathology of visna and maedi in sheep, in: Slow Virus Diseases of Animals and Man (R. Kimberlin, ed.), North Holland, Amsterdam, pp. 61–96.Google Scholar
  39. 39.
    Georgsson, G., Pâlsson, P. A., Panitch, H., Nathanson, N. and Pétursson, G., 1977, Ultra-structure of early visna lesions, Acta Neuropathol. (Berl.) 37: 127–135.CrossRefGoogle Scholar
  40. 40.
    Pâlsson, P. A., Georgsson, G., Pétursson, G., and Nathanson, N., 1977, Experimental visna in Icelandic lambs, Acta Vet. Scand. 18: 122–128.PubMedGoogle Scholar
  41. 41.
    Georgsson, G., Pétursson, G., Miller, A., Nathanson, N., and Pâlsson, P. A., 1978, Experimental visna in foetal Icelandic sheep, j Comp. Pathol. 88: 597–605.PubMedCrossRefGoogle Scholar
  42. 42.
    Georgsson, G., Martin, J. R., Pâlsson, P. A., Nathanson, N., Benediktsdóttir, E., and Pétursson, G., 1979, An ultrastructural study of the cerebrospinal fluid in visna, Acta Neuropathol. (Berl.) 48: 39–43.CrossRefGoogle Scholar
  43. 43.
    Georgsson, G., Martin, J. R., Klein, J., Pâlsson, P. A., Nathanson, N., and Pétursson, G., 1982, Primary demyelination in visna: An ultrastructural study of Icelandic sheep with clinical signs following experimental infection, Acta Neuropathol. (Berl.) 57: 171–178.CrossRefGoogle Scholar
  44. 44.
    Oliver, R. E., Gorham, J. R., Parish, S. E, Hadlow, W. J., and Narayan, O., 1981, Ovine progressive pneumonia. Pathologic and virologic studies on the naturally occurring disease, Am. J. Vet. Res. 42: 1554–1559.PubMedGoogle Scholar
  45. 45.
    Nathanson, N., Pétursson, G., Georgsson, G., Pâlsson, P. A., Martin, J. R., and Miller, A., 1979, Pathogenesis of visna. IV. Spinal fluid studies, J Neuropathol. Exp. Neurol. 38: 197–208.PubMedCrossRefGoogle Scholar
  46. 46.
    Griffin, D. E., Narayan, O., Bukowski, J. E, Adams, R. J., and Cohen, S. R., 1978, The cerebrospinal fluid in visna, a slow viral disease of sheep, Ann. Neurol. 4: 212–218.PubMedCrossRefGoogle Scholar
  47. 47.
    Herndon, R. M., and Johnson, M., 1970, A method for the electron microscopic study of cerebrospinal fluid sediment, J Neuropathol. Exp. Neurol. 29: 320–330.PubMedCrossRefGoogle Scholar
  48. 48.
    Herndon, R. M., and Kasckow, J., 1978, Electron microscopic studies of cerebrospinal fluid sediment in demyelinating disease, Ann Neurol. 4: 515–623.PubMedCrossRefGoogle Scholar
  49. 49.
    Whitaker, J. N., 1977, Myelin encephalitogenic protein fragments in cerebrospinal fluid of persons with multiple sclerosis, Neurology 27: 911–920.PubMedGoogle Scholar
  50. 50.
    Stowring, L., Haase, A. T., Pétursson, G., Georgsson, G., Pâlsson, P. A., Lutley, R., Roos, R., and Szuchet, S., 1985, Detection of visna virus antigens and RNA in glial cells in foci of demyelination, Virology 141: 311–318.PubMedCrossRefGoogle Scholar
  51. 51.
    Georgsson, G., Houwers, D. J., Pâlsson, P. A., and Pétursson, G., 1989, Expression of viral antigens in the central nervous system of visna-infected sheep: An immunohistochemical study on experimental visna induced by virus strains of increased neurovirulence, Acta Neuropathol. (Berl.) 77: 299–306.CrossRefGoogle Scholar
  52. 52.
    Gudnadóttir, M., and Kristinsdóttir, K., 1967, Complement-fixing antibodies in sera of sheep affected with visna and maedi, J. Immunol. 98: 663–667.PubMedGoogle Scholar
  53. 53.
    Thormar, H., 1969, Visna and maedi virus antigen in infected cell cultures studied by the fluorescent antibody technique, Acta Pathol. Microbiol. Scand. 75: 296–302.PubMedGoogle Scholar
  54. 54.
    de Boer, G. E, 1970, Antibody formation in zwoegerziekte, a slow infection in sheep, J. Immunol. 104: 414–422.PubMedGoogle Scholar
  55. 55.
    Terpstra, C., and De Boer, G. E, 1973, Precipitating antibodies against maedi—visna virus in experimentally infected sheep, Arch. Ges. Virusforsch. 43: 53–62.PubMedCrossRefGoogle Scholar
  56. 56.
    Cutlip, R. C., Jackson, T. A., and Laird, G. A., 1977, Immunodiffusion test for ovine progressive pneumonia, Am. J. Vet. Res. 38: 1081–1084.PubMedGoogle Scholar
  57. 57.
    Klein, J. R., Martin, J. R., Griffing, G., Nathanson, N., Gorham, J., Shen, D. T., Pétursson, G., Georgsson, G., Pâlsson, P. A., and Lutley, R., 1985, Precipitating antibodies in experimental visna and natural progressive pneumonia of sheep, Res. Vet. Sci. 38: 129–133.PubMedGoogle Scholar
  58. 58.
    Karl, S. C., and Thormar, H., 1971, Antibodies produced by rabbits immunized with visna virus, Infect. Immun. 4: 715–719.PubMedGoogle Scholar
  59. 59.
    Houwers, D. J., Gielkens, A. L. J., and Schaake, J. Jr., 1982, An indirect enzyme-linked immunosorbent assay (ELISA) for the detection of antibodies to maedi-visna virus, Vet. Microbiol. 7: 209–210.PubMedCrossRefGoogle Scholar
  60. 60.
    Gudnadóttir, M., and Palsson, P. A., 1965, Host—virus interaction in visna infected sheep, J. Immunol. 95: 1116–1120.PubMedGoogle Scholar
  61. 61.
    Lutley, R., Pétursson, G., Pdisson, P. A., Georgsson, G., Klein, J., and Nathanson, N., 1983, Antigenic drift in visna: Virus variation during long-term infection of Icelandic sheep, J. Gen. Virol. 64: 1433–1440.PubMedCrossRefGoogle Scholar
  62. 62.
    Scott, J. V., Stowring, L., Haase, A. T., Narayan, O., and Vigne, R., 1979, Antigenic variation in visna virus, Cell 18: 321–327.PubMedCrossRefGoogle Scholar
  63. 63.
    Pétursson, G., Douglas, B. M., and Lutley, R., 1974, Immunoglobulin subclass distribution and restriction of antibody response in visna, in Slow viruses in Sheep, Goats and Cattle ( J. M. Sharp and R. Hoff-Jorgensen, eds.), Commission of the European Communities, Luxembourg, pp. 211–216.Google Scholar
  64. 64.
    Martin, J. R., Goudswaard, J., Palsson, P. A., Georgsson, G., Pétursson, G., Klein, J., and Nathanson, N., 1982, Cerebrospinal fluid immunoglobulins in sheep with visna, a slow virus infection of the central nervous system, J. Neuroimmunol. 3: 139–148.PubMedCrossRefGoogle Scholar
  65. 65.
    Pétursson, G., Nathanson, N., P`alsson, P. A., Martin, J. R., and Georgsson, G., 1978, Immunopathogenesis of visna, a slow virus disease of the central nervous system, Acta Neurol. Scand. 57: 205–219.Google Scholar
  66. 66.
    Sihvonen, L., 1981, Early immune responses in experimental maedi, Res. Vet. Sci. 30: 217–222.PubMedGoogle Scholar
  67. 67.
    Larsen, H. J., Hyllseth, B., and Krogsrud, J., 1982, Experimental maedi virus infection in sheep: Early cellular and humoral immune response following parenteral inoculation, Am. J. Vet. Res. 43: 379–383.PubMedGoogle Scholar
  68. 68.
    Larsen, H. J., Hyllseth, B., and Krogsrud, J., 1982, Experimental maedi virus infection in sheep: Cellular and humoral immune response during three years following intranasal inoculation, Am. J. Vet. Res. 43: 384–389.PubMedGoogle Scholar
  69. 69.
    Trowbridge, R. S., 1975, Long-term visna virus infection of sheep choroid plexus cells: Initiation and preliminary characterization of the carrier cultures, Infect. Immun. 11: 862–868.PubMedGoogle Scholar
  70. 70.
    Carroll, D., Ventura, P., Haase, A., Rinaldo, C. R., Jr., Overall, J. C., Jr., and Glasgow, L. A., 1978, Resistance of visna virus to interferon, J. Infect. Dis. 138: 614–617.PubMedCrossRefGoogle Scholar
  71. 71.
    Narayan, O., Sheffer, D., Clements, J. E., and Tennekoon, G., 1985, Restricted replication of lentiviruses. Visna viruses induce a unique interferon during interaction between lymphocytes and infected macrophages, J. Exp. Med. 162: 1954–1969.PubMedCrossRefGoogle Scholar
  72. 72.
    Pétursson, G., 1986, Maedi—visna and scrapie in sheep, recent developments, in: Proceedings XVth Nordic Veterinary Congress, Sveriges Veterinärfòrbund ( Swedish Veterinary Society ), Stockholm, pp. 273–276.Google Scholar
  73. 73.
    Cutlip, R. C., Lehmkuhl, H. D., Brogden, K. A., and Schmerr, M. J. E, 1987, Failure of experimental vaccines to protect against infection with ovine progressive pneumonia (maedi virus) virus, Vet. Microbiol. 13: 201–204.Google Scholar
  74. 74.
    Nathanson, N., Martin, J. R., Georgsson, G., Pälsson, P. A., Lutley, R. E., and Pétursson, G., 1981, The effect of post-infection immunization on the severity of experimental visna, J. Comp. Pathol. 91: 185–191.PubMedCrossRefGoogle Scholar
  75. 75.
    McGuire, T. C., Adams, S., Johnson, G. C., Klevjer-Anderson, P., Barbee D. D., and Gorham, J. R., 1986, Acute arthritis in caprine arthritis-encephalitis virus challenge exposure of vaccinated or persistently infected goats, Am. J. Vet. Res. 47: 537–540.PubMedGoogle Scholar
  76. 76.
    Gudnadóttir, M., and Pälsson, P. A., 1967, Transmission of maedi by inoculation of a virus grown in tissue culture from maedi-affected lungs, J. Infect. Dis. 117: 1–6.PubMedCrossRefGoogle Scholar
  77. 77.
    Peluso, R., Haase, A., Stowring, L., Edwards, M., and Ventura, P., 1985, A Trojan horse mechanism for the spread of visna in monocytes, Virology 147: 231–236.PubMedCrossRefGoogle Scholar
  78. 78.
    Wekerle, H., Linington, C., Lassman, H., and Meyermann, R., 1986, Cellular immune reactivity within the CNS, Trends Neurosci. 9: 271–277.CrossRefGoogle Scholar
  79. 79.
    Nathanson, N., Panitch, H., Pälsson, P. A., Pétursson, G., and Georgsson, G., 1976, Pathogenesis of visna, II. Effect of immunosuppression upon early central nervous system lesions, Lab. Invest. 35: 444–451.PubMedGoogle Scholar
  80. 80.
    Panitch, H., Pétursson, G., Georgsson, G., Pälsson, P. A., and Nathanson, N., 1976, Pathogenesis of visna, III. Immune response to central nervous system antigens in experimental allergic encephalomyelitis and visna, Lab. Invest. 35: 452–460.PubMedGoogle Scholar
  81. 81.
    Wisniewski, H. M., and Bloom, B. R., 1975, Primary demyelination as a nonspecific consequence of a cell-mediated immune reaction, J Exp. Med. 141: 346–359.PubMedCrossRefGoogle Scholar
  82. 82.
    Gudnadóttir, M., 1974, Visna—maedi in sheep, Prog. Med. Virol. 18: 336–349.PubMedGoogle Scholar
  83. 83.
    Narayan, O., Griffin, D. E., and Chase, J., 1977, Antigenic shift of visna virus in persistently infected sheep, Science 197: 376–378.PubMedCrossRefGoogle Scholar
  84. 84.
    Thormar, H., Barshatzky, M. R., Arnesen, K., and Kozlowski, P. B., 1983, The emergence of antigenic variants is a rare event in long-term visna virus infection in vivo, J Gen. Virol. 64: 1427–1432.PubMedCrossRefGoogle Scholar
  85. 85.
    Haase, A. T, 1986, The AIDS lentivirus connection, Microb. Pathogen. 1: 1–4.CrossRefGoogle Scholar
  86. 86.
    Haase, A. T., 1986, Pathogenesis of lentivirus infections, Nature 322: 130–136.PubMedCrossRefGoogle Scholar
  87. 87.
    Narayan, O., Kennedy-Stoskopf, S., Zink, M. C., 1988, Lentivirus—host interactions: Lessons from visna and caprine arthritis—encephalitis viruses, Ann. Neurol. 23: 95–100.CrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1992

Authors and Affiliations

  • Gudmundur Pétursson
    • 1
  • Ólafur S. Andrésson
    • 1
  • Gudmundur Georgsson
    • 1
  1. 1.Institute for Experimental PathologyUniversity of IcelandReykjavikIceland

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