Virus Infection of Peripheral Nerve

  • Michael C. Graves
  • Harry V. Vinters
Part of the Infectious Agents and Pathogenesis book series (IAPA)


This chapter reviews the peripheral nerve diseases associated with herpes simplex virus (HSV), varicella-zoster virus (VZV), hepatitis B virus, human cytomegalovirus (HCMV), Epstein-Barr virus (EBV), and human immunodeficiency virus (HIV). In contrast to the many viral infections of brain and spinal cord,1 peripheral nerve has not been generally recognized as a target tissue for viruses. Acute inflammatory demyelinating polyneuropathy (AIDP), like the analogous central nervous system (CNS) disease, postinfectious encephalomyelitis, is an autoimmune disease.1,2 Both may follow a systemic viral infection, but the mechanism for the autosensitization is unknown. The mechanism is better understood in hepatitis B virus neuropathy, where circulating immune complexes have been detected.3 Probably a wide variety of mechanisms are responsible for the peripheral nerve disorders that are associated with viral infection.


Human Immunodeficiency Virus Peripheral Nerve Schwann Cell Human Immunodeficiency Virus Infection Herpes Simplex Virus Type 
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Copyright information

© Plenum Press, New York 1992

Authors and Affiliations

  • Michael C. Graves
    • 1
  • Harry V. Vinters
    • 2
  1. 1.Department of Neurology, Reed Neurological Research CenterUCLA Medical CenterLos AngelesUSA
  2. 2.Department of Pathology (Neuropathology) and Brain Research InstituteUCLA Medical CenterLos AngelesUSA

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