Immune Responses and the Central Nervous System

  • William R. Tyor
  • Richard T. Johnson
Part of the Infectious Agents and Pathogenesis book series (IAPA)


The central nervous system (CNS) is relatively isolated from systemic immune responses in the absence of disease. Within the normal CNS, there is no mechanism for antibody production, no lymphatic system, and few if any phagocytic cells. The CNS has been described as an “immunologically privileged site” because of the paucity of normal immune surveillance. Consequently, when a virus penetrates the blood—brain barriers that exclude most infectious agents, the same barriers may deter viral clearance.


Major Histocompatibility Complex Natural Killer Cell Brain Parenchyma Experimental Allergic Encephalomyelitis Viral Clearance 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Plenum Press, New York 1992

Authors and Affiliations

  • William R. Tyor
    • 1
  • Richard T. Johnson
    • 1
  1. 1.Department of NeurologyJohns Hopkins University School of MedicineBaltimoreUSA

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