Bone Marrow DNA Adducts and Bone Marrow Cellularity Following Treatment with Benzene Metabolites in Vivo
Benzenel (BZ) is a widely used industrial solvent, exposure to which has been linked to the development of aplastic anemia and leukemia. BZ is an animal carcinogen (Cronkite et al., 1984), but the ultimate carcinogenic metabolite still has not been determined. Recent work in our laboratory involving the mechanism of toxicity of BZ has been concerned with the capacity of BZ or its metabolites to interact with DNA. Previous studies have identified an adduct formed by the reaction of p-benzoquinone and deoxyguanosine in vitro (Jowa et al., 1986). Our current efforts have focused on the detection of adducts between BZ metabolites and DNA in vivo.
KeywordsAplastic Anemia Adduct Formation Bone Marrow Cellularity Nucleate Bone Marrow Cell Robert Wood Johnson Medical School
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