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Dichlorobenzene Hepatotoxicity Strain Differences and Structure Activity Relationships

  • Lhanoo Gunawardhana
  • I. Glenn Sipes
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 283)

Abstract

Environmentally significant halogenated compounds include the three isomers of dichlorobenzene (DCB), i.e. ortho (1,2-DCB), meta (1,3-DCB) and para (1,4-DCB), which have been identified as contaminants in air and water at sites throughout the United States (United States Environmental Protection Agency, 1985). This environmental contamination by the dichlorobenzenes reflects their wide-spread use in industry. These compounds are extensively used as solvents, fumigants and intermediates in the production of pesticides and dyes (Hawley, 1971).

Keywords

Structure Activity Relationship United States Environmental Protection Agency Sprague Dawley Dose Solution Hepatotoxic Potential 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Brodie, B. B., Reid, W. D., Cho, A. K., Sipes, I. G. Krishna, G. and Gillete, J. R. (1971). Possible mechanism of liver necrosis caused by aromatic organic compounds. Proc. Nat. Acad. Sci. 68, 160–164.CrossRefPubMedGoogle Scholar
  2. Charbonneau, M., Strasser, J. Jr., Lock, E. A., Turner, M. J. Jr. and Swenberg, J. A. (1989). Involvement of reversible binding to 2u-globulin in 1,4-dichlorobenzene induced nephrotoxicity. Toxicol. Appl. Pharmacol. 99, 122–132.CrossRefGoogle Scholar
  3. Hawley, G. G. (1971). The Condensed Chemical Dictionary, 8th ed., pp. 283–284. Van Nostrand Reinhold, New York/London.Google Scholar
  4. Stine, E. R., Barr, J., Carter, D. E. and Sipes, I. G. (1986). Hepatotoxicity of the three isomers of dichlorobenzene as a function of chlorine position. Toxicologist 6, pp. 119.Google Scholar
  5. U.S.A. (1985). Health assessment document for chlorinated benzenes. Final Report, January, Washington, DC. EPA 600/8–84–0015F.Google Scholar

Copyright information

© Plenum Press, New York 1991

Authors and Affiliations

  • Lhanoo Gunawardhana
    • 1
  • I. Glenn Sipes
    • 1
  1. 1.Department of Pharmacology and Toxicology, College of PharmacyUniversity of ArizonaTucsonUSA

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