Dichlorobenzene Hepatotoxicity Strain Differences and Structure Activity Relationships

  • Lhanoo Gunawardhana
  • I. Glenn Sipes
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 283)


Environmentally significant halogenated compounds include the three isomers of dichlorobenzene (DCB), i.e. ortho (1,2-DCB), meta (1,3-DCB) and para (1,4-DCB), which have been identified as contaminants in air and water at sites throughout the United States (United States Environmental Protection Agency, 1985). This environmental contamination by the dichlorobenzenes reflects their wide-spread use in industry. These compounds are extensively used as solvents, fumigants and intermediates in the production of pesticides and dyes (Hawley, 1971).


Structure Activity Relationship United States Environmental Protection Agency Sprague Dawley Dose Solution Hepatotoxic Potential 
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Copyright information

© Plenum Press, New York 1991

Authors and Affiliations

  • Lhanoo Gunawardhana
    • 1
  • I. Glenn Sipes
    • 1
  1. 1.Department of Pharmacology and Toxicology, College of PharmacyUniversity of ArizonaTucsonUSA

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