Multiple Bioactivation of Chloroform: A Comparison Between Man and Experimental Animals
Chloroform carcinogenic action is species-specific and the target organ depends on the animal species (Bull, R.J., 1985). Several experimental studies have shown that B6C3F1 mice develop hepatic tumours. Sprague-Dawley (SD) rats are among the resistant animal species. Epidemiology studies have shown a correlation between human exposure to CHCl3 in drinking water and colon cancer (Gottlieb, M.S. et al., 1981). Results of human studies, however, may be affected by confounding factors, and warrant further scientific support. Therefore, we have undertaken this study to find a metabolic feature able to explain the different susceptibility of animals and man to CHCl3 toxicity.
KeywordsLiver Microsome Covalent Binding Fatty Acyl Chain Microsomal Preparation B6C3F1 Mouse
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