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Multiple Bioactivation of Chloroform: A Comparison Between Man and Experimental Animals

  • Luciano Vittozzi
  • Emanuela Testai
  • Angelo De Biasi
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 283)

Abstract

Chloroform carcinogenic action is species-specific and the target organ depends on the animal species (Bull, R.J., 1985). Several experimental studies have shown that B6C3F1 mice develop hepatic tumours. Sprague-Dawley (SD) rats are among the resistant animal species. Epidemiology studies have shown a correlation between human exposure to CHCl3 in drinking water and colon cancer (Gottlieb, M.S. et al., 1981). Results of human studies, however, may be affected by confounding factors, and warrant further scientific support. Therefore, we have undertaken this study to find a metabolic feature able to explain the different susceptibility of animals and man to CHCl3 toxicity.

Keywords

Liver Microsome Covalent Binding Fatty Acyl Chain Microsomal Preparation B6C3F1 Mouse 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

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Copyright information

© Plenum Press, New York 1991

Authors and Affiliations

  • Luciano Vittozzi
    • 1
  • Emanuela Testai
    • 1
  • Angelo De Biasi
    • 1
  1. 1.Department of Comparative Toxicology and EcotoxicologyIstituto Superiore di SanitàRomeItaly

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