Quantitating the Production of Biological Reactive Intermediates in Target Tissues: Example, Dichloromethane
Dichloromethane (CH2C12, DCM) is a widely used industrial solvent. In addition to industrial applications such as film processing, it has been used for the preparation of consumer products such as cosmetics, decaffeinated coffee, and paint strippers. With such a wide potential for human exposure to DCM, the need for a good toxicology database is obvious, and a number of acute, subchronic, and chronic studies have been conducted with this material. In general the results from these studies have been reassuring until the National Toxicology Program completed a long term inhalation bioassay of methylene chloride in rats and mice (NTP, 1985).
KeywordsSyrian Golden Hamster Inhalation Study National Toxicology Program B6C3F1 Mouse Conjugative Pathway
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