Physiological and Toxicological Roles of Hydroperoxides

  • V. Ullrich
  • M. Schatz
  • F. Meisch
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 283)


In polymorphonuclear leukocytes (PMN) arachidonic acid is converted both to (5S)-5-hydroperoxy-(E,Z,Z,Z)-6,8,11,14-eicosatetraenoic acid (5-HPETE) and to (5S,6S)-5(6)-oxido-(E,E,Z,Z)-7,9,11,14-eicosatetraenoic acid (leukotriene A4, LTA4) by the action of 5-lipoxygenase. Furthermore, the specific dioxygenation product 5- HPETE is rapidly metabolized into (5S)-5-hydroxy-(E,Z,Z,Z)-6,8,11,14-eieosatetraenoic acid (5-HETE), presumably by the action of a peroxidase on 5-HPETE. In a further enzymatic step, LTA4 is hydrolysed to give (5S,12R)-5,12-dihydroxy-(Z,E,E,Z)- 6,8,10,14-eicosatetraenoic acid (leukotriene B4, LTB4), which acts as a potent chemoattractant and thus causes further accumulation of circulating PMN (Samuelsson et al., 1987).


Arachidonic Acid Glutathione Peroxidase Human Polymorphonuclear Leukocyte Eicosatetraenoic Acid Hydroperoxide Level 
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Copyright information

© Plenum Press, New York 1991

Authors and Affiliations

  • V. Ullrich
    • 1
  • M. Schatz
    • 1
  • F. Meisch
    • 1
  1. 1.Faculty of BiologyUniversity of KonstanzFederal Republic of Germany

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