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Physiological and Toxicological Roles of Hydroperoxides

  • V. Ullrich
  • M. Schatz
  • F. Meisch
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 283)

Abstract

In polymorphonuclear leukocytes (PMN) arachidonic acid is converted both to (5S)-5-hydroperoxy-(E,Z,Z,Z)-6,8,11,14-eicosatetraenoic acid (5-HPETE) and to (5S,6S)-5(6)-oxido-(E,E,Z,Z)-7,9,11,14-eicosatetraenoic acid (leukotriene A4, LTA4) by the action of 5-lipoxygenase. Furthermore, the specific dioxygenation product 5- HPETE is rapidly metabolized into (5S)-5-hydroxy-(E,Z,Z,Z)-6,8,11,14-eieosatetraenoic acid (5-HETE), presumably by the action of a peroxidase on 5-HPETE. In a further enzymatic step, LTA4 is hydrolysed to give (5S,12R)-5,12-dihydroxy-(Z,E,E,Z)- 6,8,10,14-eicosatetraenoic acid (leukotriene B4, LTB4), which acts as a potent chemoattractant and thus causes further accumulation of circulating PMN (Samuelsson et al., 1987).

Keywords

Arachidonic Acid Glutathione Peroxidase Human Polymorphonuclear Leukocyte Eicosatetraenoic Acid Hydroperoxide Level 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1991

Authors and Affiliations

  • V. Ullrich
    • 1
  • M. Schatz
    • 1
  • F. Meisch
    • 1
  1. 1.Faculty of BiologyUniversity of KonstanzFederal Republic of Germany

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