Parenchymal and Nonparenchymal Cell Interactions in Hepatotoxicity

  • Debra L. Laskin
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 283)


Hepatic nonparenchymal cells represent approximately 30–35% of the cells in the liver. The majority of these cells, which include Kupffer cells, endothelial cells, fat storing cells and pit cells reside within the hepatic sinusoids. Because of their small size relative to hepatocytes and the small volume that they occupy in the liver, nonparenchymal liver cells have largely been ignored in studies aimed at elucidating cellular mechanisms of heptotoxicity. However, following exposure to hepatotoxic chemicals, nonparenchymal cells become “activated”. They release large quantities of highly reactive mediators such as superoxide anion and hydrogen peroxide, eicosinoids and proteolytic enzymes which have the capacity to damage hepatic tissue. Thus these cells may contribute to pathophysiologic processes leading to toxicity.


Endothelial Cell Kupffer Cell Reactive Oxygen Intermediate Nonparenchymal Cell Reactive Mediator 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Plenum Press, New York 1991

Authors and Affiliations

  • Debra L. Laskin
    • 1
  1. 1.Joint Graduate Program in ToxicologyRutgers UniversityPiscatawayUSA

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