Testicular Metabolism and Toxicity of Halogenated Propanes

  • E. Dybing
  • E. J. Soderlund
  • M. Låg
  • G. Brunborg
  • J. A. Holme
  • J. G. Omichinski
  • P. G. Pearson
  • S. D. Nelson
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 283)

Abstract

A number of cases of infertility were discovered in 1977 among men working in a factory formulating the nematocide 1,2-dibromo-3-chloropropane (DBCP) (Whorton et al., 1977). These workers were found to have azoospermia or oligospermia. In the severely affected men, testicular biopsies revealed that the seminiferous tubules were devoid of spermatogenic cells (Biava et al., 1978). A similar testicular lesion had already been reported in rats, guinea pigs, rabbits, and monkeys after repeated inhalation exposure to DBCP (Torkelson et al., 1961). Later, the rat has been demonstrated to be a sensitive species towards the acute testicular necrogenic effects of DBCP (Kluwe, 1981). In addition to testicular necrosis and atrophy, also testicular DNA damage in the rat is known to be induced by DBCP (Bradley and Dysart 1985; Soderlund et al., 1988).

Keywords

Infertility Bromine Halogen Toxicology Transferase 

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Copyright information

© Plenum Press, New York 1991

Authors and Affiliations

  • E. Dybing
    • 1
  • E. J. Soderlund
    • 1
  • M. Låg
    • 1
  • G. Brunborg
    • 1
  • J. A. Holme
    • 1
  • J. G. Omichinski
    • 2
  • P. G. Pearson
    • 3
  • S. D. Nelson
    • 3
  1. 1.Department of Environmental MedicineNational Institute of Public HealthOslo 4Norway
  2. 2.National Institutes of HealthNIDDKBethesdaUSA
  3. 3.Department of Medicinal ChemistryUniversity of WashingtonSeattleUSA

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