Glutathione Conjugation as a Mechanism of Targeting Latent Quinones to the Kidney

  • Serrine S. Lau
  • Terrence J. Monks
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 283)


One of the major difficulties in studying the toxicity of chemicals, in particular the factors contributing to target organ toxicity, is determining whether or not the ultimate (or penultimate) metabolites responsible for causing such toxicities are formed in the organ of susceptibility. This is both an interesting and challenging toxicological problem. Chemically reactive metabolites are capable of leaving the active site of the enzyme at which they are formed, of leaving the cell in which they are formed, and of leaving the organ in which they are formed. Thus, such metabolites are clearly capable of producing toxicity at sites distal to their site of formation. It is also important to note that not all chemically reactive metabolites are biologically reactive. That is, we know certain reactive metabolites are capable of interacting with cellular macromolecules without producing any discernable alteration in cellular structure or function.


Oxidative Cyclization Reactive Metabolite Lens Epithelial Cell Mercapturic Acid Renal Proximal Tubule Cell 
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Copyright information

© Plenum Press, New York 1991

Authors and Affiliations

  • Serrine S. Lau
    • 1
  • Terrence J. Monks
    • 1
  1. 1.Division of Pharmacology and Toxicology College of PharmacyUniversity of Texas at AustinAustinUSA

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