The Role of Hepatic Metabolites of Benzene in Bone Marrow Peroxidase-Mediated Myelo- and Genotoxicity

  • George Kalf
  • Robert Shurina
  • John Renz
  • Michael Schlosser
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 283)


Chronic exposure of humans to benzene causes bone marrow depression leading to pancytopenia and aplastic anemia (Goldstein, B.D., 1983). Benzene also causes genotoxic effects such as structural chromosome aberrations and DNA strand breaks (Dean, B.J., 1985) that might be related to the increased incidence of acute myelogenous leukemia that is associated with chronic exposure (Infante, P.F., White, M.C., 1983; Aksoy, M., 1985; Arp, E.W., et al., 1983).


Arachidonic Acid Micronucleus Formation Arachidonic Acid Cascade Bone Marrow Cellularity Structural Chromosome Aberration 


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Copyright information

© Plenum Press, New York 1991

Authors and Affiliations

  • George Kalf
    • 1
  • Robert Shurina
    • 1
  • John Renz
    • 1
  • Michael Schlosser
    • 1
  1. 1.The Department of Biochemistry and Molecular BiologyJefferson Medical College of Thomas Jefferson UniversityPhiladelphiaUSA

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