Peroxyl Free Radicals: Biological Reactive Intermediates Produced during Lipid Oxidation

  • Lawrence J. Marnett
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 283)


Peroxyl radicals are intermediates in the generation of hydroperoxides and are products of their metabolism. Peroxyl radicals possess a unique combination of reactivity and selectivity that enables them to diffuse to remote cellular loci and to oxidize cellular constituents to intermediates that may play a role in toxicity and carcinogenicity. Because of the widespread occurrence of polyunsaturated fatty acid hydroperoxides in the plant and animal kingdom, peroxyl radicals must be considered biological reactive intermediates of considerable toxicological importance.


Polycyclic Aromatic Hydrocarbon Mouse Skin Peroxyl Radical Alkoxyl Radical Linoleic Acid Hydroperoxide 
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Copyright information

© Plenum Press, New York 1991

Authors and Affiliations

  • Lawrence J. Marnett
    • 1
  1. 1.A.B. Hancock, Jr. Memorial Laboratory for Cancer Research Center in Molecular ToxicologyVanderbilt University School of MedicineNashvilleUSA

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