Role of Calcium in Toxic and Programmed Cell Death

  • Sten Orrenius
  • David J. McConkey
  • Pierluigi Nicotera
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 283)


An uncontrolled and sustained increase in cytosolic Ca2+ concentration has been implicated as an early event in the developement of anoxic or toxic cell injury.

More recently it has become clear that an elevation of cytosolic Ca2+ is also involved in programmed cell death in the immune system. Here, we review some of our recent studies and provide further evidence for the role of Ca2+ in cell killing.


Programme Cell Death Phorbol Ester Endonuclease Activation Sustained Elevation Thymocyte Apoptosis 


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Copyright information

© Plenum Press, New York 1991

Authors and Affiliations

  • Sten Orrenius
    • 1
  • David J. McConkey
    • 1
  • Pierluigi Nicotera
    • 1
  1. 1.Department of ToxicologyKarolinska InstitutetStockholmSweden

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