Role of Calcium in Toxic and Programmed Cell Death
An uncontrolled and sustained increase in cytosolic Ca2+ concentration has been implicated as an early event in the developement of anoxic or toxic cell injury.
More recently it has become clear that an elevation of cytosolic Ca2+ is also involved in programmed cell death in the immune system. Here, we review some of our recent studies and provide further evidence for the role of Ca2+ in cell killing.
KeywordsProgramme Cell Death Phorbol Ester Endonuclease Activation Sustained Elevation Thymocyte Apoptosis
Unable to display preview. Download preview PDF.
- Dypbukt-Källman, J., Thor, H. and Nicotera, P. (1990). Intracellular Ca2+ chelators prevent DNA damage and protect hepatoma 1c1c7 cells from killing by a redox cycling quinone. Free Rad. Res. Comm. in press.Google Scholar
- Nicotera, P., Thor, H. and Orrenius, S. (1988). Cytosolic free Ca2+ and cell killing in hepatoma 1c1c7 cells exposed to chemical anoxia. FASEB J. 3, 59–64.Google Scholar
- Orrenius, S. and Bellomo, G. (1986). Toxicological implications of perturbation of Ca2+ homeostasis in hepatocytes. In Calcium and Cell Function ( W.Y. Cheung, Ed.), Vol. VI, pp. 185–208. Academic Press, Orlando, Florida, USA.Google Scholar