Role of Calcium in Toxic and Programmed Cell Death

  • Sten Orrenius
  • David J. McConkey
  • Pierluigi Nicotera
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 283)


An uncontrolled and sustained increase in cytosolic Ca2+ concentration has been implicated as an early event in the developement of anoxic or toxic cell injury.

More recently it has become clear that an elevation of cytosolic Ca2+ is also involved in programmed cell death in the immune system. Here, we review some of our recent studies and provide further evidence for the role of Ca2+ in cell killing.


Programme Cell Death Phorbol Ester Endonuclease Activation Sustained Elevation Thymocyte Apoptosis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Plenum Press, New York 1991

Authors and Affiliations

  • Sten Orrenius
    • 1
  • David J. McConkey
    • 1
  • Pierluigi Nicotera
    • 1
  1. 1.Department of ToxicologyKarolinska InstitutetStockholmSweden

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