Tissue Difference in Expression of Cytochrome P-450 between Liver and Lung of Syrian Golden Hamsters Treated with 3- Methylcholanthrene

  • Hiroshi Fujii
  • Ikuko Sagami
  • Tetsuo Ohmachi
  • Hideaki Kikuchi
  • Minro Watanabe
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 283)


Most chemcicals formed in our environment require metabolic activation to exert their deleterious effects in target cells. The major activation pathway is oxidative metabolism mainly catalyzed by cytochrome P-450 (P-450)-dependent monooxygenase systems which have been resolved into at least two catalytic components, namely a species of P-450 and NADPH-cytochrome c (P-450) reductase. Furthermore, multiple forms of P-450 have been isolated and purified from some species of experimental animals including Syrian golden hamster and from human (Watanabe, M. et al., 1987; Guengerich, F.P. 1987; Mizokami, K. et al., (1983).


Liver Microsome Syrian Golden Hamster Microsomal Cytochrome Hamster Liver Ouchterlony Double Diffusion 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



Cytochrome P-450






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Copyright information

© Plenum Press, New York 1991

Authors and Affiliations

  • Hiroshi Fujii
    • 1
  • Ikuko Sagami
    • 1
  • Tetsuo Ohmachi
    • 1
  • Hideaki Kikuchi
    • 1
  • Minro Watanabe
    • 1
  1. 1.Department of Cancer Chemotherapy and PreventionResearch Institute for Tuberculosis and Cancer Tohoku UniversitySendai 980Japan

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