Tissue Difference in Expression of Cytochrome P-450 between Liver and Lung of Syrian Golden Hamsters Treated with 3- Methylcholanthrene
Most chemcicals formed in our environment require metabolic activation to exert their deleterious effects in target cells. The major activation pathway is oxidative metabolism mainly catalyzed by cytochrome P-450 (P-450)-dependent monooxygenase systems which have been resolved into at least two catalytic components, namely a species of P-450 and NADPH-cytochrome c (P-450) reductase. Furthermore, multiple forms of P-450 have been isolated and purified from some species of experimental animals including Syrian golden hamster and from human (Watanabe, M. et al., 1987; Guengerich, F.P. 1987; Mizokami, K. et al., (1983).
KeywordsLiver Microsome Syrian Golden Hamster Microsomal Cytochrome Hamster Liver Ouchterlony Double Diffusion
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