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Further Evidence for the Role of Myeloperoxidase in the Activation of Benzo[A]Pyrene-7,8-Dihydrodiol by Polymorpho-Nuclear Leukocytesm

  • A. Trush
  • R. L. Esterline
  • W. G. Mallet
  • D. R. Mosebrook
  • L. E. Twerdok
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 283)

Abstract

The carcinogenic initiating activity of benzo(a)pyrene has been attributed to the generation of a stereospecific bay region diolepoxide of benzo(a)pyrene-7,8-dihydrodiol (BP)diol), anti-diolepoxide 2 (Conney, 1982). Through a myeloperoxidase (MPO)- mediated reaction, polymorphonuclear leukocytes (PMNs) can activate BP-diol to a chemiluminescent dioxetane derivative and a genotoxic electrophilic intermediate, presumably BP-diolepoxide (Trush et al., 1985; Kensler et al., 1987). This study examines the ability of PMNs or MPO to generate diolepoxides from (±)BP-diol as well as the relationship between the oxidative capability of PMNs and their ability to activate BP-diol.

Keywords

Polycyclic Aromatic Hydrocarbon Polymorphonuclear Leukocyte Oxidative Capability Human PMNs Ultimate Carcinogen 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

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Copyright information

© Plenum Press, New York 1991

Authors and Affiliations

  • A. Trush
    • 1
  • R. L. Esterline
    • 1
  • W. G. Mallet
    • 1
  • D. R. Mosebrook
    • 1
  • L. E. Twerdok
    • 1
  1. 1.Department of Environmental Health Sciences Division of Toxicological SciencesJohns Hopkins School of Hygiene and Public HealthBaltimoreUSA

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