Effect of Phenol and Catechol on the Kinetics of Human Myeloperoxidase-Dependent Hydroquinone Metabolism
Benzene, is hematotoxic and leukemogenic in humans (Aksoy, M., 1987). It is widely accepted that benzene requires metabolic activation to exert its toxic and carcinogenic effects (Cooper, K.R. and Snyder, R. 1987). The majority of benzene metabolism occurs in liver with phenol (PH), hydroquinone (HQ) and catechol (CAT) being the major metabolites formed. Benzene is also oxidized to a ring-opened product trans, trans-muconic acid.
KeywordsPhenoxy Radical Phenolic Metabolite Benzene Metabolite Benzene Toxicity Benzene Metabolism
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