Effect of Phenol and Catechol on the Kinetics of Human Myeloperoxidase-Dependent Hydroquinone Metabolism

  • Vangala V. Subrahmanyam
  • Prema Kolachana
  • Martyn T. Smith
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 283)


Benzene, is hematotoxic and leukemogenic in humans (Aksoy, M., 1987). It is widely accepted that benzene requires metabolic activation to exert its toxic and carcinogenic effects (Cooper, K.R. and Snyder, R. 1987). The majority of benzene metabolism occurs in liver with phenol (PH), hydroquinone (HQ) and catechol (CAT) being the major metabolites formed. Benzene is also oxidized to a ring-opened product trans, trans-muconic acid.


Phenoxy Radical Phenolic Metabolite Benzene Metabolite Benzene Toxicity Benzene Metabolism 
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Copyright information

© Plenum Press, New York 1991

Authors and Affiliations

  • Vangala V. Subrahmanyam
    • 1
  • Prema Kolachana
    • 1
  • Martyn T. Smith
    • 1
  1. 1.Department of Biomedical and Environmental Health Sciences School of Public HealthUniversity of California at BerkeleyBerkeleyUSA

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