A Reduction in Mixed Function Oxidases and in Tumor Promoting Effects of Ethanol in a NDEA-Initiated Hepatocarcinogenesis Model

  • Siraj I. Mufti
  • I. Glenn Sipes
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 283)


Epidemiologic studies associate an increased cancer risk with chronic alcohol consumption [for example, Hakulinen et al., 1974; Breslow and Enstrom, 1974; Feldman et al., 1985; Williams and Horn, 1977; Schottenfeld, 1979; Kono and Ikeda, 1979; Tnyns, 1979; Doll and Peta, 1981]. However, the experimental evidence for this association is not clear. While a number of studies indicate that ethanol, the active ingredient of alcoholic beverages, increases the incidence of chemically induced tumors [for example, Gibel, 1967; Griciute et al., 1982; Gabriel et al., 1982; McCoy et al., 1986], other studies do not show such an effect [Schmahl et al., 1965; Sehmahl, 1976; Habs and Sehmahl, 1981; Teschke et al., 1983]. We recently reported studies that showed that ethanol increased tumor incidence only when administered as a tumor promoter after treatment with an esophagus specific carcinogen, N-nitrosomethylbenzlamine (NMBzA) was completed [Mufti et al., 1989]. In these studies we wanted to determine the effect of ethanol when given as a tumor promoter on liver carcinogenesis induced by N-nitrosodiethylamine (NDEA). The paper offers an explanation for the negative results obtained in these studies.


Ethanol Consumption Mixed Function Oxidase Chronic Alcohol Consumption Chronic Ethanol Consumption NADPH Cytochrome 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Plenum Press, New York 1991

Authors and Affiliations

  • Siraj I. Mufti
    • 1
  • I. Glenn Sipes
    • 1
  1. 1.Department of Pharmacology and ToxicologyThe University of Arizona College of PharmacyTucsonUSA

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