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Contribution of 3,4-Dichlorophenylhydroxylamine in Propanil-Induced Hemolytic Anemia

  • David C. McMillan
  • Timothy P. Bradshaw
  • JoEllyn M. McMillan
  • Jack A. Hinson
  • David J. Jollow
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 283)

Abstract

The methemoglobinemia and hemolytic anemia observed in experimental animals given aniline has been shown to be mediated by its N-oxidation metabolite, phenylhydroxylamine (Harrison, J.H. et al., 1987; Harrison, J.H. et al., 1986). The aniline derivative, propanil (3,4-dichloropropionanilide), is a widely used arylamide herbicide that has been shown to induce methemoglobinemia in experimental animals following conversion of the parent amide to one or more oxidized metabolites (Singleton, S > D. et al., 1973; Chow, A.Y.K. et al., 1975). Two methemoglobinemic metabolites of propanil have been identified, 3,4-dichlorophenylhydroxylamine (N-hydroxy-3,4-dichloroaniline) and 6-hydroxy-3,4-dichloroaniline (McMillan, D.C. et al., 1990). In view of the hemolytic activity of phenylhydroxylamine, we have examined the hemolytic potential of propanil and its metabolites in rats.

Keywords

Hemolytic Anemia Hemolytic Activity Erythrocyte Suspension Aniline Derivative Erythrocyte Membrane Protein 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

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Copyright information

© Plenum Press, New York 1991

Authors and Affiliations

  • David C. McMillan
    • 1
  • Timothy P. Bradshaw
    • 1
  • JoEllyn M. McMillan
    • 1
  • Jack A. Hinson
    • 2
  • David J. Jollow
  1. 1.Department of PharmacologyMedical University of South CarolinaCharlestonUSA
  2. 2.National Center for Toxicological ResearchJeffersonUSA

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