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Structure-Activity Relationships of Acrylate Esters: Reactivity Towards Glutathione and Hydrolysis by Carboxylesterase in Vitro

  • T. J. McCarthy
  • G. Witz
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 283)

Abstract

Acrylate esters are high volume, versatile chemicals in the plastics industry. Long)term industrial exposure to these esters has caused contact hypersensitivity and dermatitis, while laboratory studies have shown these esters to be strong irritants, sensitizers, clastogens, and some have been shown to be weak carcinogens (Andrews and Clary, 1986). Numerous members make up this class of chemicals sharing an α, β- unsaturated ester structure. The individual members differ from each other due to structural features added onto the α, β-unsaturated ester.

Keywords

Methyl Acrylate Butyl Acrylate Ethyl Acrylate Ethyl Methacrylate Butyl Ester 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Andrews, L.S., and Clary, J.J. (1986). Review of the toxicity of multifunctional acrylates. J. Toxicol. Environ. Health 19, 149–164.CrossRefPubMedGoogle Scholar
  2. Beutler, E., Duron, E., and Kelly, B. (1961). Improved method for determining blood glutathione. J. Lab. Clin. Med. 61, 882–888.Google Scholar
  3. Miller, R.R., Ayres, J.A., Rampy, L.W., and McKenna, M.J. (1981). Metabolism of acrylate esters in rat tissue homogenates. Fundam. Appt. Toxicol. 1, 410–414.CrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1991

Authors and Affiliations

  • T. J. McCarthy
    • 1
  • G. Witz
    • 1
  1. 1.Joint Graduate Program in ToxicologyRutgers University/UMDNJ-RW Johnson Medical SchoolPiscatawayUSA

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