The Antidotal Activity of the Thiol Drug Diethyldithiocarbamate Against N-Acetyl-p-Benzoquinone Imine in Isolated Hepatocytes

  • Veronique V. Lauriault
  • Peter J. O’Brien
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 283)


N-Acetyl-p-benzoquinone imine (NAPQI) is the putativereactive metabolite implicated in acetaminophenhepatotoxicity (Crocoran et al., Dahlin et al., Albano et al., and Rundgren et al.) which is a highly reactive electrophile as well as an oxidant (Rundgren et al.). Toxicity in isolated hepatocytes has been attibuted to the alkylation and/or oxidation of protein thiol groups (Albano et al. and Rundgren et al.).


Allyl Alcohol Protein Thiol Iodoacetic Acid GSSG Level Protein Thiol Group 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Abbreviations used








N-Acetyl-p-Benzoquinone Imine


reduced glutathione


oxidised glutathione


4-(2-hydroxyethyl)-1-piperazine-ethane-sulphonic acid


high performance liquid chromatography


fast atom bombardment


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Copyright information

© Plenum Press, New York 1991

Authors and Affiliations

  • Veronique V. Lauriault
    • 1
  • Peter J. O’Brien
    • 1
  1. 1.Faculty of PharmacyUniversity of TorontoTorontoCanada

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