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Role of the Acetone Inducible P-450IIE1 in the Deethylation of Diethylnitrosamine in Hamster

  • P. G. Gervasi
  • P. Puccini
  • V. Longo
  • A. Lippi
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 283)

Abstract

Nitrosamines are well known carcinogenic compounds that require a metabolic activation to generate electrophilic species able to elicit toxic, mutagenic or carcinogenic damage in cells. This activation process, generally involving an α-Chydroxylation has been shown to be a cytochrome P-450 dependent reaction.

Keywords

Hepatic Microsome Microsomal Metabolism Aniline Hydroxylase Hamster Liver Electrophilic Species 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

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Copyright information

© Plenum Press, New York 1991

Authors and Affiliations

  • P. G. Gervasi
    • 1
  • P. Puccini
    • 1
  • V. Longo
    • 1
  • A. Lippi
    • 1
  1. 1.Istituto di Mutagenesi e DifferenziamentoCNRPisaItaly

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