Role of the Acetone Inducible P-450IIE1 in the Deethylation of Diethylnitrosamine in Hamster
Nitrosamines are well known carcinogenic compounds that require a metabolic activation to generate electrophilic species able to elicit toxic, mutagenic or carcinogenic damage in cells. This activation process, generally involving an α-Chydroxylation has been shown to be a cytochrome P-450 dependent reaction.
KeywordsHepatic Microsome Microsomal Metabolism Aniline Hydroxylase Hamster Liver Electrophilic Species
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