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Stereochemical Induction of Cytochrome P450IVA1 (P452) and Peroxisome Proliferation in Male Rat

  • Edwin C. Chinje
  • G. Gordon Gibson
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 283)

Abstract

Peroxisome proliferator xenobiotics (including clofibrate, a hypolipidaemic drug) are a class of non-genotoxic hepatocarcinogen in sensitive species such as the rat and mouse and result in characteristic liver responses including hepatomegaly, peroxisome proliferation and induction of microsomal cytochrome P450IVA1 (P452)-dependent fatty acid hydroxylase.

Keywords

Lauric Acid Peroxisome Proliferation Pure Enantiomer Carnitine Acetyl Transferase Hypolipidaemic Drug 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Lake, B.G., Gray, T.J.B., Pels Rijcken, W.R., Beamand, J.A. and Gangolli, S.D. (1984). Xenobiotica 14, 269–276.CrossRefPubMedGoogle Scholar
  2. Milton, M.N. (1989). PhD. Thesis, University of Surrey, England.Google Scholar
  3. Sharma, R., Lake, B.G. and Gibson, G.G. (1988). Biochem. Pharmacol. 37, 1203–1206.CrossRefPubMedGoogle Scholar
  4. Sharma, R., Lake,B.G., Foster, J. and Gibson, G.G. (1988). Biochem Pharmacol. 37, 1193–1201.CrossRefPubMedGoogle Scholar

Copyright information

© Plenum Press, New York 1991

Authors and Affiliations

  • Edwin C. Chinje
    • 1
  • G. Gordon Gibson
    • 1
  1. 1.Molecular Toxicology Group and Department of BiochemistryUniversity of SurreyGuildford, SurreyEngland, UK

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