Stereochemical Induction of Cytochrome P450IVA1 (P452) and Peroxisome Proliferation in Male Rat

  • Edwin C. Chinje
  • G. Gordon Gibson
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 283)


Peroxisome proliferator xenobiotics (including clofibrate, a hypolipidaemic drug) are a class of non-genotoxic hepatocarcinogen in sensitive species such as the rat and mouse and result in characteristic liver responses including hepatomegaly, peroxisome proliferation and induction of microsomal cytochrome P450IVA1 (P452)-dependent fatty acid hydroxylase.


Lauric Acid Peroxisome Proliferation Pure Enantiomer Carnitine Acetyl Transferase Hypolipidaemic Drug 
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Copyright information

© Plenum Press, New York 1991

Authors and Affiliations

  • Edwin C. Chinje
    • 1
  • G. Gordon Gibson
    • 1
  1. 1.Molecular Toxicology Group and Department of BiochemistryUniversity of SurreyGuildford, SurreyEngland, UK

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