Stereochemical Induction of Cytochrome P450IVA1 (P452) and Peroxisome Proliferation in Male Rat
Peroxisome proliferator xenobiotics (including clofibrate, a hypolipidaemic drug) are a class of non-genotoxic hepatocarcinogen in sensitive species such as the rat and mouse and result in characteristic liver responses including hepatomegaly, peroxisome proliferation and induction of microsomal cytochrome P450IVA1 (P452)-dependent fatty acid hydroxylase.
KeywordsLauric Acid Peroxisome Proliferation Pure Enantiomer Carnitine Acetyl Transferase Hypolipidaemic Drug
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