Molecular Targets of Chemical Mutagens

  • Bradley D. Preston
  • Rupa Doshi
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 283)


Most mutagens are biologically active by virtue of their chemical reactivity. The pioneering work of the Millers (reviewed in Miller and Miller, 1974, 1981) and others (Searle, 1984 and references therein) clearly established that most chemical mutagens (or their metabolites) are electrophilic and covalently bind to cellular macromolecules. Proteins were first identified as cellular targets (Miller, 1951), and it was soon recognized that RNA and DNA are also extensively damaged by mutagens (for reviews see: Searle, 1984; Miller and Miller, 1974). Theoretically, every cellular nucleophile is a potential target for damage by electrophilic mutagens.


Replication Fork Ribonucleotide Reductase Exonuclease Activity Purine Nucleoside Phosphorylase dNTP Pool 
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Copyright information

© Plenum Press, New York 1991

Authors and Affiliations

  • Bradley D. Preston
    • 1
  • Rupa Doshi
    • 1
  1. 1.Department of Chemical BiologyRutgers University College of PharmacyPiscatawayUSA

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