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Formation of a Protein-Acetaldehyde Adduct in Liver during Chronic Alcohol Exposure

  • Renee C. Lin
  • Lawrence Lumeng
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 283)

Abstract

Acetaldehyde is an intermediary metabolite of ethanol oxidation that forms in the liver during alcohol ingestion. Formation of acetaldehyde is mediated by two alcohol metabolizing systems: alcohol dehydrogenase (ADH) (Li, 1977) and the microsomal ethanol oxidizing system (MEOS or cytP450IIE1) (Lieber et al., 1970). In individuals who do not abuse alcohol, ADH is the most important enzyme responsible for the conversion of ethanol to acetaldehyde. However, MEOS is inducible by chronic alcohol consumption (Lieber, et al., 1972), therefore its contribution to the elimination of alcohol becomes more significant in chronic alcoholics.

Keywords

Alcohol Dehydrogenase Liquid Diet 37KD Protein Ethanol Oxidation Acetaldehyde Concentration 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1991

Authors and Affiliations

  • Renee C. Lin
    • 1
  • Lawrence Lumeng
    • 1
  1. 1.Departments of Medicine and BiochemistryIndiana University School of Medicine, and the Veterans Affairs Medical CenterIndianapolisUSA

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