Formation of a Protein-Acetaldehyde Adduct in Liver during Chronic Alcohol Exposure
Acetaldehyde is an intermediary metabolite of ethanol oxidation that forms in the liver during alcohol ingestion. Formation of acetaldehyde is mediated by two alcohol metabolizing systems: alcohol dehydrogenase (ADH) (Li, 1977) and the microsomal ethanol oxidizing system (MEOS or cytP450IIE1) (Lieber et al., 1970). In individuals who do not abuse alcohol, ADH is the most important enzyme responsible for the conversion of ethanol to acetaldehyde. However, MEOS is inducible by chronic alcohol consumption (Lieber, et al., 1972), therefore its contribution to the elimination of alcohol becomes more significant in chronic alcoholics.
KeywordsAlcohol Dehydrogenase Liquid Diet 37KD Protein Ethanol Oxidation Acetaldehyde Concentration
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