Formation of Reactive Metabolites and Appearance of Antiorganelle Antibodies in Man
The toxic effects of many xenobiotics are very often not due to the parent compound itself but to reactive intermediates or metabolites formed in situ inside the cell. These reactive species may bind covalently to cell proteins leading to various cell disorders and eventually to toxic effects.
KeywordsHuman Liver Microsome Reactive Metabolite Thiophene Ring Tienilic Acid Human Liver Cytochrome
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