Abstract
Risk assessment benefits enormously from the mechanistic data derived from research activity in toxicology which utilizes biological systems that range from whole animal, whole organ, organ slices, cells to the molecular level. New research techniques and instrumentation have vastly improved our ability to investigate complex toxicokinetic questions and to determine the roles for very small quantities of both low and high molecular weight molecules in toxic events. Some of these advances will be discussed relative to the requirements for making predictions for risk assessment associated with exposure to toxic chemicals.
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© 1991 Plenum Press, New York
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Reed, D.J. (1991). Future Research Needs for the Application of Mechanistic Data to Risk Assessment. In: Witmer, C.M., Snyder, R.R., Jollow, D.J., Kalf, G.F., Kocsis, J.J., Sipes, I.G. (eds) Biological Reactive Intermediates IV. Advances in Experimental Medicine and Biology, vol 283. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5877-0_122
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DOI: https://doi.org/10.1007/978-1-4684-5877-0_122
Publisher Name: Springer, Boston, MA
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