Future Research Needs for the Application of Mechanistic Data to Risk Assessment

  • Donald J. Reed
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 283)


Risk assessment benefits enormously from the mechanistic data derived from research activity in toxicology which utilizes biological systems that range from whole animal, whole organ, organ slices, cells to the molecular level. New research techniques and instrumentation have vastly improved our ability to investigate complex toxicokinetic questions and to determine the roles for very small quantities of both low and high molecular weight molecules in toxic events. Some of these advances will be discussed relative to the requirements for making predictions for risk assessment associated with exposure to toxic chemicals.


Mechanistic Data Pulse Laser Ablation Risk Assessment Benefit Standard Polymerase Chain Reaction Allyl Isothiocyanate 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. Ames, B.N., Magaw, R. and Gold, L. S. (1987). Ranking Possible Carcinogenic Hazards. Science, 236 271–280.CrossRefPubMedGoogle Scholar
  2. Ames, B. M., Profet, M. and Gold, L. S. Dietary Pesticides (99.99% All Natural), Mitogenesis, Mutagenesis, and Carcinogenesis, Mutagens in Food: Detection and Prevention, H. Hayatsu, Ed. (CRC Press, Inc. Boca Raton, Fl) in press.Google Scholar
  3. Bruckner, J.V., Davis, B.D. and Blancato, J.N. (1989). Metabolism, Toxicity, and Carcinogenicity of Trichlorethylene. Crit. Rev. Toxicol, 20, 31–50.CrossRefPubMedGoogle Scholar
  4. Covey, T. R., Bonner, R. F., Shushan, B. I., and Henion, J. (1988). The Determination of Protein, Oligonucleotide and Peptide Molecular Weights by Ion-spray Mass Spectrometry. Rapid Communications in Mass Spectrometry, 2, 249–256.Google Scholar
  5. Guyer, R. L. and Koshland, D. E. Jr. (1989). Perspective “The Molecule of the Year.” Science, 246, 1543–1546.CrossRefPubMedGoogle Scholar
  6. Karas, M., Ingendoh, A., Bahr, U., and Hillenkamp,F. (1989). Ultraviolet-Laser Desorption/Ionization Mass Spectrometry of Femtomolar Amounts of Large Proteins. Biomedical Environmental Mass Spectrometry, 641–643.Google Scholar
  7. Koizumi, A. (1989). Potential of Physiologically Based Pharmacokinetics to Amalgamate Kinetic Data of Trichloroethylene and Tetrachloroethylene Obtained in Rats and Man. Br. J. Ind. Med 46, 239–249.PubMedGoogle Scholar
  8. Nelson, R. W., Rainbow, J. J., Lohr, D. E., and Williams,P. (1989). Volatilzation of High Molecular Weight DNA by Pulsed Laser Ablation of Frozen Aqueous Solutions. Science, 246, 1585–1587.CrossRefPubMedGoogle Scholar
  9. Reitz, R.H., Mendrala, A.L., and Guengerich,F.P. (1989). In vitro Metabolism of Methylene Chloride in Human and Animal Tissues: Use in Physiologically Based Pharmacokinetic Models. Toxicol. Appl. Pharmacol, 97, 230–246.Google Scholar
  10. Slovic, P. (1987). Perception of Risk. Science, 236, 280–285.CrossRefPubMedGoogle Scholar
  11. Slovic, P. (1986). Informing and Educating the Public About Risk. Risk Analysis, 6, 403–415.CrossRefPubMedGoogle Scholar
  12. Starr, C. (1969). Social Benefit versus Technological Risk. Science, 165, 1232–1238.CrossRefPubMedGoogle Scholar
  13. Wildaysky, A. (1979). No Risk Is the Highest Risk of All. Am. Sci, 67, 32–37.Google Scholar

Copyright information

© Plenum Press, New York 1991

Authors and Affiliations

  • Donald J. Reed
    • 1
  1. 1.Department of Biochemistry and Biophysics and Environmental Health Sciences CenterOregon State UniversityCorvallisUSA

Personalised recommendations