Rat Hepatic DNA Damage Induced by 1,2,3-Trichloropropane

  • Gregory L. Weber
  • I. Glenn Sipes
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 283)


1,2,3-Trichloropropane (TCP) is used as an industrial solvent and as an intermediate in pesticide and polysulfide rubber manufacturing. It is structurally similar to other halogenated alkanes with known carcinogenic potential (1,2- dibromoethane and 1,2-dibromo-3-chloropropane). Preliminary evidence from a chronic bioassay study conducted by the National Toxicology Program indicates that TCP administration results in an increased incidence of tumors in both male and female F-344 rats and B6C3F1 mice (Mahmood et al.,1988).


Single Strand Break National Toxicology Program Alkaline Elution Tetrapropylammonium Hydroxide Mesh Wire Screen 
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Copyright information

© Plenum Press, New York 1991

Authors and Affiliations

  • Gregory L. Weber
    • 1
  • I. Glenn Sipes
    • 1
  1. 1.Department of Pharmacology and Toxicology College of PharmacyUniversity of ArizonaTucsonUSA

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