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Hapten Carrier Conjugates Associated with Halothane Hepatitis

  • Lance R. Pohl
  • David Thomassen
  • Neil R. Pumford
  • Lynn E. Butler
  • Hiroko Satoh
  • Victor J. Ferrans
  • Andrea Perrone
  • Brian M. Martin
  • Jackie L. Martin
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 283)

Abstract

The elucidation of the mechanism of hepatitis caused by the inhalation anesthetic agent halothane (CF3CHClBr) (Satoh et al., 1987; Neuberger and Kenna, 1987; Weis and Engelhardt, 1989) is important since halothane is still widely used in adults in the United Kingdom and Europe (Neuberger and Kenna, 1987; Weis and Engelhardt, 1989) and is often an agent of choice for children (Hals et al., 1986; Whitburn and Sumner, 1986; Kenna et al., 1987a). Also, recent reports suggest that the structurally related inhalation anesthetic enflurane (CHF2OCF2CHFCl), which is widely used in adults in the United States, may cause liver damage by a similar process (Christ et al., 1988a; Christ et al., 1988b).

Keywords

Endoplasmic Reticulum Liver Microsome Protein Disulfide Isomerase Halothane Hepatitis Malfolded Protein 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1991

Authors and Affiliations

  • Lance R. Pohl
    • 1
  • David Thomassen
    • 1
  • Neil R. Pumford
    • 1
  • Lynn E. Butler
    • 1
  • Hiroko Satoh
    • 1
  • Victor J. Ferrans
    • 1
    • 2
  • Andrea Perrone
    • 1
  • Brian M. Martin
    • 1
    • 3
  • Jackie L. Martin
    • 1
  1. 1.Laboratory of Chemical PharmacologyNational Heart, Lung, and Blood InstituteBethesdaUSA
  2. 2.Pathology Branch, Ultrastructure SectionNational Heart, Lung, and Blood InstituteBethesdaUSA
  3. 3.Clinical Neurosciences BranchNational Institute of Mental Health National Institutes of HealthBethesdaUSA

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