Antioxidation Potential of Indole Compounds — Structure Activity Studies
Many indole compounds, including dietary indoles such as indole-3-carbinol [I-3- C], have been shown to protect against chemical carcinogenesis (Wattenberg 1983) and chemically induced hepatotoxicity (Shertzer et al. 1987a, 1987b, 1988a). Such protection may be due to the ability of I-3-C to scavenge biologically reactive electrophiles (Shertzer et al. 1987b, 1988b) and free radicals (Shertzer et al. 1987a; Shertzer et al. 1988a). To develop better chemoprotective indoles with lower intrinsic toxicity, 28 structurally related indoles were investigated relative to antioxidant efficacies and physicochemical properties (Log P and electronic effects).
KeywordsIndole Compound Antioxidant Potency Antioxidant Efficacy Indole Nucleus Calculated Partition Coefficient
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