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Antioxidation Potential of Indole Compounds — Structure Activity Studies

  • M. Wilson Tabor
  • Eugene Coats
  • Malcolm Sainsbury
  • Howard G. Shertzer
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 283)

Abstract

Many indole compounds, including dietary indoles such as indole-3-carbinol [I-3- C], have been shown to protect against chemical carcinogenesis (Wattenberg 1983) and chemically induced hepatotoxicity (Shertzer et al. 1987a, 1987b, 1988a). Such protection may be due to the ability of I-3-C to scavenge biologically reactive electrophiles (Shertzer et al. 1987b, 1988b) and free radicals (Shertzer et al. 1987a; Shertzer et al. 1988a). To develop better chemoprotective indoles with lower intrinsic toxicity, 28 structurally related indoles were investigated relative to antioxidant efficacies and physicochemical properties (Log P and electronic effects).

Keywords

Indole Compound Antioxidant Potency Antioxidant Efficacy Indole Nucleus Calculated Partition Coefficient 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Hansch, C. and Leo, A.J. (1979). Substituent constants for correlation analysis in chemistry and biology, John Wiley and Sons, New York.Google Scholar
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Copyright information

© Plenum Press, New York 1991

Authors and Affiliations

  • M. Wilson Tabor
    • 1
  • Eugene Coats
    • 2
  • Malcolm Sainsbury
    • 3
  • Howard G. Shertzer
    • 1
  1. 1.Institute Environmental HealthUniversity of Cincinnati Medical CenterCincinnatiUSA
  2. 2.College of PharmacyUniversity of Cincinnati Medical CenterCincinnatiUSA
  3. 3.University of BathBathEngland

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