Evidence for the Induction of an Oxidative Stress in Rat Hepatic Mitochondria by 2,3,7,8-Tetrachlorodibenzo-P-Dioxin (TCDD)

  • S. J. Stohs
  • N. Z. Alsharif
  • M. A. Shara
  • Z. A. F. Al-Bayati
  • Z. Z. Wahba
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 283)


TCDD is prototypical of a large number of halogenated polycyclic hydrocarbons that occur as environmental contaminants and pollutants (Safe, 1986; Poland and Knutson, 1982; Poland et al., 1985). Following the acute exposure to a toxic dose of TCDD and its bioisosteres, a progressive weight loss with hypophagia and depletion of adipose tissue occurs (Safe, 1986; Kociba and Schwetz, 1982; Neal et al., 1982; Poland and Knutson, 1982). In addition, hepatic, gastric and epidermal lesions, thymic involution, and increased excretion of porphyrins occur (Poland and Knutson, 1982; Kociba and Schwetz, 1982). Evidence indicates that the mechanism of toxicity of TCDD and its bioisosteres involves binding to a specific TCDD (Ah) receptor, interaction of this complex with chromatin, and the ultimate production of a pleiotropic response (Cook et al., 1987; Safe, 1988; Poland and Knutson, 1982). the post-translational pathways and mechanisms involved in the expression of the toxic effects of TCDD are not known.


Lipid Peroxidation Membrane Fluidity Calcium Content Polycyclic Hydrocarbon Interscapular Brown Adipose Tissue 
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Copyright information

© Plenum Press, New York 1991

Authors and Affiliations

  • S. J. Stohs
    • 1
  • N. Z. Alsharif
    • 1
  • M. A. Shara
    • 1
  • Z. A. F. Al-Bayati
    • 1
  • Z. Z. Wahba
    • 1
  1. 1.School of Pharmacology and Allied HealthCreighton UniversityOmahaUSA

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