Biochemical and Morphologic Response of Nasal Epithelia to Hyperoxia
The nasal epithelium of people receiving oxygen therapy can be exposed to up to 100% oxygen by intranasal cannulae. The morphologic effect of hyperoxia on nasal epithelia has not been studied, but it is known that another oxidant, ozone, induces hyperplasia and metaplasia of the nasal epithelium. The purpose of our study was to examine the effects of acute and chronic hyperoxia on nasal epithelial morphology, and on antioxidant enzyme and cytochrome P450-dependent monooxygenase activities in nasal epithelium.
KeywordsBasal Lamina Olfactory Epithelium Nasal Septum Nasal Epithelium Oxygen Exposure
Unable to display preview. Download preview PDF.