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Biochemical and Morphologic Response of Nasal Epithelia to Hyperoxia

  • Patrick J. Sabourin
  • Kristen J. Nikula
  • Amie J. Birdwhistell
  • Breton C. Freitag
  • Jack R. Harkema
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 283)

Abstract

The nasal epithelium of people receiving oxygen therapy can be exposed to up to 100% oxygen by intranasal cannulae. The morphologic effect of hyperoxia on nasal epithelia has not been studied, but it is known that another oxidant, ozone, induces hyperplasia and metaplasia of the nasal epithelium. The purpose of our study was to examine the effects of acute and chronic hyperoxia on nasal epithelial morphology, and on antioxidant enzyme and cytochrome P450-dependent monooxygenase activities in nasal epithelium.

Keywords

Basal Lamina Olfactory Epithelium Nasal Septum Nasal Epithelium Oxygen Exposure 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1991

Authors and Affiliations

  • Patrick J. Sabourin
    • 1
  • Kristen J. Nikula
    • 1
  • Amie J. Birdwhistell
    • 1
  • Breton C. Freitag
    • 1
  • Jack R. Harkema
    • 1
  1. 1.Lovelace Inhalation Toxicology Research InstituteAlbuquerqueUSA

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