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Reactive Potential of Diethylstilbestrol Reactive Metabolites Towards Cellular Nuclear Proteins: Implications for Estrogen*Induced Carcinogenesis

  • Deodutta Roy
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 283)

Abstract

Diethylstilbestrol (DES), a synthetic estrogen, has increasingly been associated with human cancer (IARC 1979). Over the years, DES has been shown to induce tumors in reproductive- and various other organs in animals (IARC 1979). The exact mechanism of estrogen-induced carcinogenesis is not understood. A role of reactive metabolites in estrogen-induced carcinogenesis has been postulated (Metzler, 1987), because hormonal potency could not be correlated with tumor incidence.

Keywords

Nuclear Protein Covalent Binding Syrian Hamster Reactive Metabolite Synthetic Estrogen 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1991

Authors and Affiliations

  • Deodutta Roy
    • 1
  1. 1.Department of Pharmacology and ToxicologyUniversity of Texas Medical BranchGalvestonUSA

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