Reactive Potential of Diethylstilbestrol Reactive Metabolites Towards Cellular Nuclear Proteins: Implications for Estrogen*Induced Carcinogenesis
Diethylstilbestrol (DES), a synthetic estrogen, has increasingly been associated with human cancer (IARC 1979). Over the years, DES has been shown to induce tumors in reproductive- and various other organs in animals (IARC 1979). The exact mechanism of estrogen-induced carcinogenesis is not understood. A role of reactive metabolites in estrogen-induced carcinogenesis has been postulated (Metzler, 1987), because hormonal potency could not be correlated with tumor incidence.
KeywordsNuclear Protein Covalent Binding Syrian Hamster Reactive Metabolite Synthetic Estrogen
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