Modulation of Aortic Smooth Muscle Cell Prolifertion by Dinitrotoluene

  • Kenneth S. Ramos
  • K. McMahon
  • C. Alipui
  • D. Demick
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 283)


Technical grade dinitrotoluene (DNT) is a mixture of approximately 76% 2,4DNT, 19% 2,6-DNT and 5% other isomers. Because DNT is commonly used in the manufacture of explosives and several commercial products, concerns have been raised that this chemical might represent a significant occupational hazard (Levine, 1987). Toxicity studies in rodents have shown that prolonged administration of DNT causes cancers of the liver, gall bladder, and kidney and benign tumors of connective tissues. Bond et al. (1981) have proposed that the hepatocarcinogenic effect of DNT is mediated by a toxic metabolite formed by intestinal flora upon reduction of nitrobenzylalcohol, an oxidative metabolite of dinitrotoluene.


Smooth Muscle Cell Thymidine Incorporation Aortic Smooth Muscle Cell Cardiovascular Toxicity Smooth Muscle Cell Growth 
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Copyright information

© Plenum Press, New York 1991

Authors and Affiliations

  • Kenneth S. Ramos
    • 1
  • K. McMahon
    • 1
  • C. Alipui
    • 3
  • D. Demick
    • 2
  1. 1.Department of Veterinary Physiology and PharmacologyTexas A&M UniversityCollege StationUSA
  2. 2.Departments of PathologyTexas Tech University Health Sciences CenterLubbockUSA
  3. 3.Departments of PharmacologyTexas Tech University Health Sciences CenterLubbockUSA

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