Modulation of Aortic Smooth Muscle Cell Prolifertion by Dinitrotoluene
Technical grade dinitrotoluene (DNT) is a mixture of approximately 76% 2,4DNT, 19% 2,6-DNT and 5% other isomers. Because DNT is commonly used in the manufacture of explosives and several commercial products, concerns have been raised that this chemical might represent a significant occupational hazard (Levine, 1987). Toxicity studies in rodents have shown that prolonged administration of DNT causes cancers of the liver, gall bladder, and kidney and benign tumors of connective tissues. Bond et al. (1981) have proposed that the hepatocarcinogenic effect of DNT is mediated by a toxic metabolite formed by intestinal flora upon reduction of nitrobenzylalcohol, an oxidative metabolite of dinitrotoluene.
KeywordsSmooth Muscle Cell Thymidine Incorporation Aortic Smooth Muscle Cell Cardiovascular Toxicity Smooth Muscle Cell Growth
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