Abstract
In addition to being a primary source for the generation of biological reactive intermediates (BRI), cytochromes P-450 often serve as target molecules for these intermediates. Specific binding of BRI to individual forms of cytochrome P-450 may be exploited in the design of irreversible inhibitors known as mechanism-based inactivators. The high degreeof selectivity often attainable with such compounds makes them particularly attractive for in vivo applications (Rando, 1984; Ortiz de Montellano et al., 1986).
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© 1991 Plenum Press, New York
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Halpert, J.R., Stevens, J.C. (1991). Cytochrome P-450 as a Target of Biological Reactive Intermediates. In: Witmer, C.M., Snyder, R.R., Jollow, D.J., Kalf, G.F., Kocsis, J.J., Sipes, I.G. (eds) Biological Reactive Intermediates IV. Advances in Experimental Medicine and Biology, vol 283. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5877-0_11
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DOI: https://doi.org/10.1007/978-1-4684-5877-0_11
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