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Cytochrome P-450 as a Target of Biological Reactive Intermediates

  • James R. Halpert
  • Jeffrey C. Stevens
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 283)

Abstract

In addition to being a primary source for the generation of biological reactive intermediates (BRI), cytochromes P-450 often serve as target molecules for these intermediates. Specific binding of BRI to individual forms of cytochrome P-450 may be exploited in the design of irreversible inhibitors known as mechanism-based inactivators. The high degreeof selectivity often attainable with such compounds makes them particularly attractive for in vivo applications (Rando, 1984; Ortiz de Montellano et al., 1986).

Keywords

Congenital Adrenal Hyperplasia Inactivation Process Tienilic Acid Acyl Halide Heme Moiety 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1991

Authors and Affiliations

  • James R. Halpert
    • 1
  • Jeffrey C. Stevens
    • 1
  1. 1.Department of Pharmacology and Toxicology, College of PharmacyUniversity of ArizonaTucsonUSA

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