Cytochrome P-450 as a Target of Biological Reactive Intermediates
In addition to being a primary source for the generation of biological reactive intermediates (BRI), cytochromes P-450 often serve as target molecules for these intermediates. Specific binding of BRI to individual forms of cytochrome P-450 may be exploited in the design of irreversible inhibitors known as mechanism-based inactivators. The high degreeof selectivity often attainable with such compounds makes them particularly attractive for in vivo applications (Rando, 1984; Ortiz de Montellano et al., 1986).
KeywordsCongenital Adrenal Hyperplasia Inactivation Process Tienilic Acid Acyl Halide Heme Moiety
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