Cytochrome P-450 as a Target of Biological Reactive Intermediates

  • James R. Halpert
  • Jeffrey C. Stevens
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 283)


In addition to being a primary source for the generation of biological reactive intermediates (BRI), cytochromes P-450 often serve as target molecules for these intermediates. Specific binding of BRI to individual forms of cytochrome P-450 may be exploited in the design of irreversible inhibitors known as mechanism-based inactivators. The high degreeof selectivity often attainable with such compounds makes them particularly attractive for in vivo applications (Rando, 1984; Ortiz de Montellano et al., 1986).


Congenital Adrenal Hyperplasia Inactivation Process Tienilic Acid Acyl Halide Heme Moiety 
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Copyright information

© Plenum Press, New York 1991

Authors and Affiliations

  • James R. Halpert
    • 1
  • Jeffrey C. Stevens
    • 1
  1. 1.Department of Pharmacology and Toxicology, College of PharmacyUniversity of ArizonaTucsonUSA

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